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Phone: (843) 766-6635
Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
9 a.m. - 1 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
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Low‐level laser activates Wnt/β‐catenin signaling pathway‐promoting hair follicle stem cell regeneration and wound healing: Upregulate the expression of key downstream gene Lef 1.
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- Author(s): BangHong, Jiang1 (AUTHOR); YuKun, Wang1 (AUTHOR); Ao, Shi2 (AUTHOR); Tao, Sun3 (AUTHOR); PeiJun, Song1 (AUTHOR); XuWen, Li1 (AUTHOR); Lin, Li1 (AUTHOR); ZhuYou, Xiong1 (AUTHOR); Li, Zhang1 (AUTHOR)
- Source:
Skin Research & Technology. Jun2024, Vol. 30 Issue 6, p1-10. 10p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Background: The objective of this study is to investigate the mechanism by which low‐level laser stimulation promotes the proliferation of intraepithelial hair follicle stem cells (HFSCs) in wounds. This research aims to expand the applications of laser treatment, enhance wound repair methods, and establish a theoretical and experimental foundation for achieving accelerated wound healing. Methods: The experimental approach involved irradiating a cell model with low‐level laser to assess the proliferation of HFSCs and examine alterations in the expression of proteins related to the Wnt/β‐catenin signaling pathway. A mouse back wound model was established to investigate the effects of low‐level laser irradiation on wound healing rate, wound microenvironment, and the proliferation of HFSCs in relation to the Wnt/β‐catenin signaling pathway. Results: The research findings indicate that low‐level laser light effectively activates the Wnt signaling pathway, leading to the increased accumulation of core protein β‐catenin and the upregulation of key downstream gene Lef 1. Consequently, this regulatory mechanism facilitates various downstream biological effects, including the notable promotion of HFSC proliferation and differentiation into skin appendages and epithelial tissues. As a result, the process of wound healing is significantly accelerated. Conclusion: Low levels of laser activates the Wnt signalling pathway, promotes the regeneration of hair follicle stem cells and accelerates wound healing. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Skin Research & Technology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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