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Risk of periodontitis in adolescents with bipolar disorder: a cohort study of 21,255 subjects.
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- Author(s): Wu, Ping-Chung; Tsai, Shih-Jen; Hsu, Ju-Wei; Huang, Kai-Lin; Chen, Tzeng-Ji; Chen, Mu-Hong
- Source:
European Child & Adolescent Psychiatry. May2024, Vol. 33 Issue 5, p1529-1537. 9p. - Source:
- Additional Information
- Subject Terms: RISK assessment; BIPOLAR disorder; RESEARCH funding; SEX distribution; TRANQUILIZING drugs; DESCRIPTIVE statistics; LONGITUDINAL method; CONFIDENCE intervals; COMPARATIVE studies; PERIODONTITIS; PROPORTIONAL hazards models; REGRESSION analysis; DISEASE risk factors; DISEASE complications; ADOLESCENCE
- Abstract: Although a growing number of studies have investigated the relationship between psychosocial factors and periodontitis, studies investigating the association between bipolar disorder (BD) and periodontitis are lacking. Using the Taiwan National Health Insurance Research Database, 4251 adolescents with BD and 17,004 age- and sex-matched controls were included. They were followed up from enrollment to the end of 2011 or death. Periodontitis was diagnosed during the follow-up. Cox regression analysis indicated that adolescents with BD had a higher risk of periodontitis (hazard ratio [HR]: 2.96, 95% confidence interval [CI] 2.77–3.17) than did controls. Subanalyses stratified by sex revealed a higher risk of periodontitis in male (HR: 2.83, 95% CI 2.56–3.14) and female (HR: 3.01, 95% CI 2.74–3.30) adolescents with BD than their respective controls. The long-term use of mood stabilizers was associated with a higher risk of periodontitis (HR: 1.19, 95% CI 1.06–1.35) in the BD cohort. Our study highlighted an increased risk of periodontitis in adolescents with BD compared with controls during the follow-up. We recommend that more attention should be paid to the prevention of periodontitis in adolescents with BD, especially those who are female or receiving mood stabilizers. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Child & Adolescent Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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