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Relative contribution of COVID-19 vaccination and SARS-CoV-2 infection to population-level seroprevalence of SARS-CoV-2 spike antibodies in a large integrated health system.
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- Author(s): Chervo, Tyler C.; Elkin, Eric P.; Nugent, Joshua R.; Valice, Emily; Amsden, Laura B.; Ergas, Isaac J.; Munneke, Julie R.; Flores, Monica; Saelee, Gina N.; Hsiao, Crystal A.; Schapiro, Jeffery M.; Quesenberry, Charles P.; Corley, Douglas A.; Habel, Laurel A.; Kushi, Lawrence H.; Skarbinski, Jacek
- Source:
PLoS ONE; 6/20/2024, Vol. 19 Issue 6, p1-16, 16p- Subject Terms:
- Source:
- Additional Information
- Abstract: Background: Understanding the relative contributions of SARS-CoV-2 infection-induced and vaccine-induced seroprevalence is key to measuring overall population-level seroprevalence and help guide policy decisions. Methods: Using a series of six population-based cross-sectional surveys conducted among persons aged ≥7 years in a large health system with over 4.5 million members between May 2021 and April 2022, we combined data from the electronic health record (EHR), an electronic survey and SARS-CoV-2 spike antibody binding assay, to assess the relative contributions of infection and vaccination to population-level SARS-CoV-2 seroprevalence. EHR and survey data were incorporated to determine spike antibody positivity due to SARS-CoV-2 infection and COVID-19 vaccination. We used sampling and non-response weighting to create population-level estimates. Results: We enrolled 4,319 persons over six recruitment waves. SARS-CoV-2 spike antibody seroprevalence increased from 83.3% (CI 77.0–88.9) in May 2021 to 93.5% (CI 89.5–97.5) in April 2022. By April 2022, 68.5% (CI 61.9–74.3) of the population was seropositive from COVID-19 vaccination only, 13.9% (10.7–17.9) from COVID-19 vaccination and prior diagnosed SARS-CoV-2 infection, 8.2% (CI 4.5–14.5) from prior diagnosed SARS-CoV-2 infection only and 2.9% (CI 1.1–7.6) from prior undiagnosed SARS-CoV-2 infection only. We found high agreement (≥97%) between EHR and survey data for ascertaining COVID-19 vaccination and SARS-CoV-2 infection status. Conclusions: By April 2022, 93.5% of persons had detectable SARS-CoV-2 spike antibody, predominantly from COVID-19 vaccination. In this highly vaccinated population and over 18 months into the pandemic, SARS-CoV-2 infection without COVID-19 vaccination was a small contributor to overall population-level seroprevalence. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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