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West Ashley Library
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Phone: (843) 766-6635
Folly Beach Library
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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
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McClellanville Library
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Keith Summey North Charleston Library
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Hurd/St. Andrews Library
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Dorchester Road Library
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Phone: (843) 722-7550
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9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
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Phone: (843) 805-6909
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Site-specific pegylated IL2 mutein with biased IL2 receptor binding for cancer immunotherapy.
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- Author(s): Tong, Bei1 (AUTHOR); Leong, Sirou Grace2 (AUTHOR); Jian, Tunyu1 (AUTHOR); Niu, Guanting1 (AUTHOR); Gai, Yanan1 (AUTHOR); Meng, Xiuhua1 (AUTHOR); Lv, Han1 (AUTHOR); Dong, Xianchi1,2,3 (AUTHOR) ; Ding, Xiaoqin1 (AUTHOR) ; Chen, Jian1 (AUTHOR)
- Source:
International Immunopharmacology. Jul2024, Vol. 136, pN.PAG-N.PAG. 1p.- Subject Terms:
- Source:
- Additional Information
- Abstract: • PEGylation is advantageous for extending the in vivo half-life of IL2. • Constructing IL2 mutant to impart a bias towards inducing effector T cells. • EC50 ratio of Mo7e and CTLL-2 cells is an indicator for immunotherapy evaluation. While Interleukin 2 (IL2) has the capability to activate both NK and T cells robustly, its limited in vivo half-life, considerable toxicity, and tendency to boost Treg cells pose significant challenges, restricting its widespread application in cancer therapy. In this investigation, we engineered a novel IL2 variant (IL2-4M-PEG) with reduced CD25 binding activity and an extended half-life by substituting amino acids associated with CD25 binding and implementing site-directed PEGylation. IL2-4M-PEG notably amplifies effector cells over Treg cells. Furthermore, our findings reveal that IL2-4M-PEG, characterized by an extended half-life, exhibits anti-tumor effects in a mouse model. Consequently, this innovative IL2 holds the potential for enhancing combined cancer therapies in the future. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of International Immunopharmacology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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