Toxicological assessment of glyphosate exposure on warm-blooded animals in long-term administration.

Introduction For several decades, glyphosate has been one ofthe most widely used herbicides in the world, but the safety of glyphosate and its commercial formulations is still controversial. Methods In order to achieve the degree of the damaging effect of glyphosate acid on the body during its long-term intake, a study was made of the chronic effect of a.i. and specially prepared soybeans (heat-treated to deactivate the trypsin inhibitor) at doses of 0, 0.15, 20, 200, 2000, and 20,000 ppm. For comparison, two control groups were identified: 1k - on a standard diet, 2k - with the addition of soy-beans. The toxic effect was assessed by changes in integral, hematological, biochemical and physiological parameters within 12 months. Results There were no statistically significant differences in the summation threshold indicator, as well as behavioral reactions (general activity, path length, rest time, mink reflex, orienting reaction). As a result of the glyphosate acid consumption with soy for 3 months, a statistically significant increase in platelets, an increase in the activity of AP, ALT, albumin, cholesterol and glucose levels at a dose of 20,000 ppm were obtained compared to the control. There were no statistically significant changes in the activity of enzymes of the antioxidant defense system in the blood of rats relative to the control values. No statistically significant changes of hematological parameters in experimental doses compared with control values were found after 6 months; after 12 months - statistically significant changes are observed only in the highest experimental dose (20,000 ppm) compared with control values and are manifested in an increase in the content of erythrocytes, hemoglobin and platelets. After 6 months of the consumption of glyphosate acid with soy, a significant decrease in the activity of AST, LDH, AP and the content of creatinine, triglycerides, chlorides were obtained in the highest dose of 20,000 ppm compared to the control 1k. There was a statistically significant decrease in AST activity at a dose of20,000 ppm compared with the values of the control group 2k. After 12 months of consumption of glyphosate acid with soy, a significant decrease in AST activity and creatinine content was obtained when exposed to the highest dose compared to the 1k control, an increase in cholesterol at the same dose relative to the 2k group. There were no statistically significant changes in the activity of enzymes of the antioxidant defense system in the rats' blood relative to control values after 6 months from the start of the treatment. After 12 months - there is a decrease in the activity of glutathione reductase at a dose of 20,000 ppm relative to the two control groups. Conclusions The remaining experimental doses showed no effect when exposed to the body of warm-blooded animals in a chronic experiment with soy. Thus, the results of the conducted studies don't contradict the previously established toxicity parameters of glyphosate acid. [ABSTRACT FROM AUTHOR]

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