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Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight.
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- Author(s): Houerbi, Nadia; Kim, JangKeun; Overbey, Eliah G.; Batra, Richa; Schweickart, Annalise; Patras, Laura; Lucotti, Serena; Ryon, Krista A.; Najjar, Deena; Meydan, Cem; Damle, Namita; Chin, Christopher; Narayanan, S. Anand; Guarnieri, Joseph W.; Widjaja, Gabrielle; Beheshti, Afshin; Tobias, Gabriel; Vatter, Fanny; Hirschberg, Jeremy Wain; Kleinman, Ashley
- Source:
Nature Communications; 6/11/2024, Vol. 15 Issue 1, p1-17, 17p- Subject Terms:
- Source:
- Additional Information
- Abstract: As spaceflight becomes more common with commercial crews, blood-based measures of crew health can guide both astronaut biomedicine and countermeasures. By profiling plasma proteins, metabolites, and extracellular vesicles/particles (EVPs) from the SpaceX Inspiration4 crew, we generated "spaceflight secretome profiles," which showed significant differences in coagulation, oxidative stress, and brain-enriched proteins. While >93% of differentially abundant proteins (DAPs) in vesicles and metabolites recovered within six months, the majority (73%) of plasma DAPs were still perturbed post-flight. Moreover, these proteomic alterations correlated better with peripheral blood mononuclear cells than whole blood, suggesting that immune cells contribute more DAPs than erythrocytes. Finally, to discern possible mechanisms leading to brain-enriched protein detection and blood-brain barrier (BBB) disruption, we examined protein changes in dissected brains of spaceflight mice, which showed increases in PECAM-1, a marker of BBB integrity. These data highlight how even short-duration spaceflight can disrupt human and murine physiology and identify spaceflight biomarkers that can guide countermeasure development. Here the authors report spaceflight secretome profiles by integrating plasma proteome, metabolome, and extracellular vesicles/particles proteome from the SpaceX Inspiration4 crew, which showed differences in coagulation, oxidative stress, and brain-enriched proteins. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Nature Communications is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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