Menu
×
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
Folly Beach Library
9 a.m. - 5:30 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 6 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 8 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. – 8 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. - 4 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. – 8 p.m.
Phone: (843) 552-6466
John L. Dart Library
9 a.m. – 7 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
9 a.m. – 8 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. – 8 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Apolipoprotein (a) levels in type 1 and type 2 diabetes mellitus.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Ruotolo G;Ruotolo G; Zoppo A; Parlavecchia M; Giberti B; Micossi P
- Source:
Acta diabetologica [Acta Diabetol] 1991; Vol. 28 (2), pp. 158-61.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print Cited Medium: Print ISSN: 0940-5429 (Print) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
- Publication Information: Publication: Berlin : Springer Verlag
Original Publication: Berlin : Springer International, c1991- - Subject Terms: Lipoprotein(a)*; Apolipoproteins/*blood ; Diabetes Mellitus, Type 1/*blood ; Diabetes Mellitus, Type 2/*blood ; Diabetic Angiopathies/*diagnosis; Adult ; Aged ; Apoprotein(a) ; Biomarkers/blood ; Cholesterol/blood ; Cholesterol, HDL/blood ; Diabetic Angiopathies/blood ; Female ; Humans ; Male ; Middle Aged ; Reference Values ; Risk Factors ; Triglycerides/blood
- Abstract: Type 1 and type 2 diabetes mellitus are both characterized by increased cardiovascular mortality and morbidity. Since several reports have indicated that apolipoprotein (a) [apo(a)] levels are positively associated with an increased risk of macrovascular disease, we investigated whether apo(a) levels are elevated in both types of diabetes mellitus and may thus represent an independent risk factor for atherosclerotic disease. Apo(a) concentrations in type 1 diabetic patients were not significantly different from matched controls (276 +/- 78 vs 149 +/- 46 units/l). Type 2 diabetic patients had considerably higher levels of apo(a) than matched controls (471 +/- 89 vs 221 +/- 61 units/l, P = 0.06), though the difference was not statistically significant. However, concentrations of apo(a) were above 300 units/l in 36% of type 1 and 67% of type 2 diabetic patients, but in only 14% and 25% respectively of matched control subjects. Plasma triglycerides were positively and independently correlated with apo(a) levels in both diabetic and non-diabetic subjects. On the other hand, no significant correlation was found between apo(a) levels and glycosylated haemoglobin, total cholesterol or high density lipoprotein cholesterol in any of the groups studied. In conclusion, apo(a) levels are not significantly elevated either in type 1 or type 2 diabetic patients without proteinuria and in moderate metabolic control; however, levels above 300 units/l were 2.6 times more frequent in both types of diabetes mellitus than in carefully age-, sex-, and weight-matched control subjects.
- References: J Biol Chem. 1984 Sep 25;259(18):11470-8. (PMID: 6236225)
Arch Intern Med. 1972 Dec;130(6):833-43. (PMID: 5082462)
J Clin Invest. 1986 Feb;77(2):622-30. (PMID: 2935560)
J Clin Invest. 1987 Aug;80(2):458-65. (PMID: 2956279)
Gerontology. 1982 Nov-Dec;28(6):381-5. (PMID: 6219044)
Diabetes Care. 1991 Apr;14(4):283-7. (PMID: 1829404)
Acta Pathol Microbiol Scand. 1963;59:369-82. (PMID: 14064818)
JAMA. 1990 Jan 5;263(1):35-6. (PMID: 2136711)
J Clin Invest. 1990 Jun;85(6):1709-15. (PMID: 2140835)
J Clin Invest. 1980 Jun;65(6):1483-90. (PMID: 7410552)
N Engl J Med. 1990 May 24;322(21):1494-9. (PMID: 2139920)
Diabetes Care. 1991 Apr;14(4):302-7. (PMID: 1829405)
Methods Enzymol. 1986;128:354-64. (PMID: 3724512)
Atherosclerosis. 1981 Jan-Feb;38(1-2):51-61. (PMID: 7470205)
Clin Genet. 1974;6(3):230-5. (PMID: 4372011)
Diabetologia. 1987 Mar;30(3):144-8. (PMID: 3582820)
J Lipid Res. 1991 Apr;32(4):679-83. (PMID: 1830325)
Circulation. 1986 Oct;74(4):758-65. (PMID: 2944670)
Atherosclerosis. 1986 Dec;62(3):249-57. (PMID: 2948513)
Clin Genet. 1975 Sep;8(3):183-9. (PMID: 170031)
Lancet. 1988 May 14;1(8594):1070-3. (PMID: 2896911)
Science. 1989 Nov 17;246(4932):904-10. (PMID: 2530631)
Br Med J (Clin Res Ed). 1983 Sep 24;287(6396):867-70. (PMID: 6412862)
Atherosclerosis. 1983 Dec;49(3):277-93. (PMID: 6229255)
JAMA. 1986 Nov 14;256(18):2540-4. (PMID: 2945939) - Accession Number: 0 (Apolipoproteins)
0 (Biomarkers)
0 (Cholesterol, HDL)
0 (Lipoprotein(a))
0 (Triglycerides)
97C5T2UQ7J (Cholesterol)
EC 3.4.21.- (Apoprotein(a)) - Publication Date: Date Created: 19910101 Date Completed: 19920309 Latest Revision: 20191028
- Publication Date: 20221213
- Accession Number: 10.1007/BF00579719
- Accession Number: 1777652
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.