Renal function in non-insulin-dependent diabetes mellitus: purposes and design of the Diabetic Renal Disease Study.

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  • Author(s): Nelson RG;Nelson RG
  • Source:
    Acta diabetologica [Acta Diabetol] 1991; Vol. 28 (2), pp. 143-50.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9200299 Publication Model: Print Cited Medium: Print ISSN: 0940-5429 (Print) Linking ISSN: 09405429 NLM ISO Abbreviation: Acta Diabetol Subsets: MEDLINE
    • Publication Information:
      Publication: Berlin : Springer Verlag
      Original Publication: Berlin : Springer International, c1991-
    • Subject Terms:
      Albuminuria* ; Kidney Function Tests*; Diabetes Mellitus, Type 2/*physiopathology ; Diabetic Nephropathies/*physiopathology ; Kidney/*physiopathology; Adult ; Arizona ; Blood Glucose/analysis ; Blood Pressure ; Creatinine/blood ; Creatinine/urine ; Female ; Glucose Tolerance Test ; Glycated Hemoglobin/analysis ; Glycosuria ; Humans ; Immunoglobulin G/urine ; Indians, North American ; Longitudinal Studies ; Male ; Middle Aged ; Renin/blood
    • Abstract:
      Type 2, non-insulin-dependent diabetes mellitus accounts for 60% of the end-stage renal disease attributed to diabetes in the United States, yet little is known about glomerular function or the development of renal disease in this type of diabetes. The Diabetic Renal Disease Study (DRDS) is a longitudinal study designed to elucidate the natural history of renal disease and to characterize glomerular function throughout the course of renal disease in type 2, non-insulin-dependent diabetes mellitus. The study is being conducted among the Pima Indians from the Gila River Indian Community in Arizona because they experience a very high rate of type 2 diabetes mellitus, which often develops at a young age and which is frequently associated with the development of renal disease. Glomerular filtration rate, renal plasma flow, albumin and IgG excretion, level of vasoactive hormones, retinal damage, and glomerular capillary permeability to dextrans of different sizes will be assessed at regular intervals over 48 months in six groups of subjects representing a range of glucose tolerance from normal to diabetes, and among the diabetic subjects, a range of proteinuria from normal to overt diabetic nephropathy. The DRDS is designed to provide new information on the functional determinants of renal disease in type 2, non-insulin-dependent diabetes mellitus and will serve as the basis for designing intervention strategies.
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    • Grant Information:
      N01-DK-6-2285 United States DK NIDDK NIH HHS; N01-DK-7-2291 United States DK NIDDK NIH HHS
    • Accession Number:
      0 (Blood Glucose)
      0 (Glycated Hemoglobin A)
      0 (Immunoglobulin G)
      AYI8EX34EU (Creatinine)
      EC 3.4.23.15 (Renin)
    • Publication Date:
      Date Created: 19910101 Date Completed: 19920309 Latest Revision: 20221207
    • Publication Date:
      20240627
    • Accession Number:
      10.1007/BF00579717
    • Accession Number:
      1777650