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The association of depressive symptoms with adverse clinical outcomes in hypertension: Data from SPRINT randomized trail.
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- Author(s): Zhou, Junfeng1 (AUTHOR) ; Zeng, Zhao1,2 (AUTHOR); He, Liudang1,2 (AUTHOR); Guo, Cuirong1,2 (AUTHOR); Ding, Ning1,2 (AUTHOR) ; Su, Yingjie1,2 (AUTHOR) ; Qin, Jiao1,3 (AUTHOR)
- Source:
Journal of Affective Disorders. Aug2024, Vol. 359, p59-69. 11p.- Subject Terms:
- Source:
- Additional Information
- Abstract: This study intends to explore the effect of depressive symptoms on adverse clinical outcomes in middle-aged and elderly hypertensive patients. This post hoc analysis was conducted using data from the Systolic Blood Pressure Intervention Trial (SPRINT), and we used cox proportional risk regression to examine the relationship between depressive symptoms and adverse clinical outcomes (primary outcome, all-cause mortality, cardiovascular disease(CVD) mortality, heart failure(HF), myocardial infarction(MI), non-myocardial infarction acute coronary syndrome(non-MI ACS)). In a follow-up study of 9259 participants, we found that depression symptoms was significantly and positively associated with the primary outcome (HR 1.03, 95%CI 1.01–1.05; p for trend = 0.0038), all-cause mortality (HR 1.03, 95%CI 1.01–1.05; p for trend = 0.0308), HF(HR 1.05, 95%CI 1.01–1.08; p for trend = 0.0107), and non-MI ACS(HR 1.06, 95%CI 1.01–1.10; p for trend = 0.0120). Kaplan-Meier survival curves for depression symptoms severity (none, mild, moderate, and above) and adverse clinical outcomes suggested that for all but primary clinical outcomes, the cumulative risk of adverse clinical outcomes increased with increasing depression symptoms severity. For middle-aged and elderly hypertensive patients, depression symptoms exacerbates the risk of adverse clinical outcomes (primary outcome, all-cause mortality, CVD death, MI, HF, and non-MI ACS), and the risk increases with the severity of depression symptoms. • The relationship between depressive symptoms and clinical outcomes in patients with hypertension was explored. • Depression could exacerbate the risk of adverse clinical outcomes. • With the severity of depression increasing, the risk of adverse clinical outcomes increases. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Affective Disorders is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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