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Early pyridoxine administration rescues autism-like behavior in the BTBR T+tf/J autistic model.
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- Author(s): Ruan, Ruotong; Shao, Wenyu; Su, Yichun; Liu, Jiayin; Luo, Jing; Luo, Yi; Wang, Lian; Fan, Xiaotang
- Source:
Research in Autism Spectrum Disorders; Jul2024, Vol. 115, pN.PAG-N.PAG, 1p - Source:
- Additional Information
- Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social impairment and repetitive, stereotyped behaviors. An imbalanced oxidative stress status and neuroinflammation are involved in ASD development. In this study, we investigated the effects of pyridoxine, a form of vitamin B6 with potent anti-oxidant and anti-inflammatory features, on autism-like behavior in BTBR T + ltpr3tf/J (BTBR) mice, a model of autism. Mice received pyridoxine from postnatal days 7 to 14. Behavioral tests were conducted on 8-week-old male mice, and the inflammatory status and oxidative stress levels were also assessed in the mouse hippocampus. Postnatal pyridoxine treatment significantly improved social deficits, stereotyped behaviors, and cognitive deficits in BTBR mice. In addition, pyridoxine treatment alleviated neuroinflammation in the hippocampus manifested by reduced Iba1+ microglia and inflammatory factors, such as interleukin-1β (IL-1β), IL-6, TNF-α, and NF-κB. Further, pyridoxine-treated BTBR mice had elevated Nrf2 and HO-1 in the hippocampus. Postnatal pyridoxine administration might improve autistic-like behaviors in BTBR mice via attenuating oxidative stress and neuroinflammation in the hippocampus. • Early postnatal pyridoxine treatment significantly improved autistic behaviors in BTBR mice. • Early postnatal pyridoxine treatment alleviated neuroinflammation in the hippocampus manifested. • Pyridoxine-treated BTBR mice had elevated Nrf2 in the hippocampus. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Research in Autism Spectrum Disorders is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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