Evaluation of total cholesterol and low-density lipopolysaccharide level as potential predictors of new incidence of diabetes mellitus in individuals with allele AC/CC polymorphism of IGF2BP2 gene.

Diabetes mellitus (DM) is the leading cause of death from non-communicable diseases after heart disease and stroke. The case continues to increase with fairly difficult management because it is multifactorial. One of the controls is early screening with diabetic markers or biomarkers using certain gene polymorphism markers. This study aims to look at the influence of SNP (single nucleotide polymorphism) IGF2BP2 rs 16860234 and biomedical parameters of total cholesterol and LDL (low-density lipoprotein) levels on new incidence of diabetes using respondents of the Non-Communicable Disease Risk Factors cohort study in Bogor. The data was descriptively analyzed to see the spread of respondents and then tested chi-square or Fisher's Exact contingency as an alternative test to see the relationship between parameters. Receiver Operating Curve (ROC) analysis is performed by selecting meaningful parameters based on under-curve area (AUC) where the optimal cut-off value of each selected parameter is calculated by the Youden Index. The results showed the sensitivity and specificity of total cholesterol levels in individuals with allele AC/CC polymorphism of the IGF2BP2 gene was 73.7% and 61.7% with cut-off values ≥209mg/dl, while LDL sensitivity and specificity were 57.9% and 77.9% with cut-off values ≥153.5 mg/dl. This suggests individuals who have allele AC/CC polymorphism of the IGF2BP2 gene, its total cholesterol and LDL levels with sensitivity and specificity >50%, are very likely to be potential predictors of new occurrences of diabetes mellitus. [ABSTRACT FROM AUTHOR]

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