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Quantifying neurodegeneration of the cervical cord and brain in degenerative cervical myelopathy: A multicentre study using quantitative magnetic resonance imaging.
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- Author(s): Freund, Patrick (AUTHOR); Boller, Viveka (AUTHOR); Emmenegger, Tim M. (AUTHOR); Akbar, Muhammad (AUTHOR); Hupp, Markus (AUTHOR); Pfender, Nikolai (AUTHOR); Wheeler‐Kingshott, Claudia Angela Michela Gandini (AUTHOR); Cohen‐Adad, Julien (AUTHOR); Fehlings, Michael G. (AUTHOR); Curt, Armin (AUTHOR); Seif, Maryam (AUTHOR)
- Source:
European Journal of Neurology. Jul2024, Vol. 31 Issue 7, p1-12. 12p. - Source:
- Additional Information
- Subject Terms:
- Subject Terms:
- Abstract: Background and purpose: Simultaneous assessment of neurodegeneration in both the cervical cord and brain across multiple centres can enhance the effectiveness of clinical trials. Thus, this study aims to simultaneously assess microstructural changes in the cervical cord and brain above the stenosis in degenerative cervical myelopathy (DCM) using quantitative magnetic resonance imaging (MRI) in a multicentre study. Methods: We applied voxelwise analysis with a probabilistic brain/spinal cord template embedded in statistical parametric mappin (SPM‐BSC) to process multi parametric mapping (MPM) including effective transverse relaxation rate (R2*), longitudinal relaxation rate (R1), and magnetization transfer (MT), which are indirectly sensitive to iron and myelin content. Regression analysis was conducted to establish associations between neurodegeneration and clinical impairment. Thirty‐eight DCM patients (mean age ± SD = 58.45 ± 11.47 years) and 38 healthy controls (mean age ± SD = 41.18 ± 12.75 years) were recruited at University Hospital Balgrist, Switzerland and Toronto Western Hospital, Canada. Results: Remote atrophy was observed in the cervical cord (p = 0.002) and in the left thalamus (0.026) of the DCM group. R1 was decreased in the periaqueductal grey matter (p = 0.014), thalamus (p = 0.001), corpus callosum (p = 0.0001), and cranial corticospinal tract (p = 0.03). R2* was increased in the primary somatosensory cortices (p = 0.008). Sensory impairments were associated with increased iron‐sensitive R2* in the thalamus and periaqueductal grey matter in DCM. Conclusions: Simultaneous assessment of the spinal cord and brain revealed DCM‐induced demyelination, iron deposition, and atrophy. The extent of remote neurodegeneration was associated with sensory impairment, highlighting the intricate and expansive nature of microstructural neurodegeneration in DCM, reaching beyond the stenosis level. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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