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West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Folly Beach Library
Closed
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 849-6161
McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
9 a.m. – 8 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
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Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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John L. Dart Library
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Phone: (843) 722-7550
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Phone: (843) 795-6679
Main Library
9 a.m. – 8 p.m.
Phone: (843) 805-6930
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Phone: (843) 805-6892
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Phone: (843) 805-6909
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Immunohistochemical Expression of Insulin-Like Growth Factor-1 Receptor and Its Association with Clinicopathological Parameters in Hepatocellular Carcinoma.
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- Author(s): Peloso Maia, Maria Luiza; Albuquerque, Ronniel Morais; do Carmo Silva, Serena Dafne; Lima, Cristiano Xavier; Costa Diniz, Paulo Henrique; Vieira Teixeira Vidigal, Paula
- Source:
Oncology; 2024, Vol. 102 Issue 6, p494-502, 9p- Subject Terms:
STATISTICAL correlation; CIRRHOSIS of the liver; RESEARCH funding; CLINICAL trials; TREATMENT effectiveness; DESCRIPTIVE statistics; TUMOR grading; IMMUNOHISTOCHEMISTRY; GENE expression; CARCINOGENS; MEDICAL records; ACQUISITION of data; CELL nuclei; RESEARCH; LIVER; COLLECTION & preservation of biological specimens; TUMORS; CONNECTIVE tissue growth factor; CELL receptors; HEPATOCELLULAR carcinoma; LIVER transplantation; DISEASE progression - Source:
- Additional Information
- Subject Terms:
- Abstract: Introduction: Hepatocellular carcinoma (HCC) carcinogenesis is not yet fully known. Insulin-like growth factor-1 receptor (IGF-1R) can translocate to the nucleus and modulate cellular growth, possibly participating in HCC development and aggressiveness. This study aimed to evaluate the immunoexpression of IGF-1R in HCC, the cellular compartment involved, and its association with clinicopathological parameters and clinical outcomes. Methods: Liver specimens from 111 HCC patients who underwent liver transplantation or partial surgical resections at a Brazilian referral hospital center were studied. IGF-1R expression was determined by immunohistochemistry, clinical data were collected from medical records, and pathological parameters were obtained from path review. Results: IGF-1R nuclear expression was higher in the tumor than in the adjacent cirrhosis (p < 0.001). The odds of IGF-1R expression in the nucleus compared to the membrane are lower in the cirrhosis condition than in the tumor, suggesting an increase in the prevalence of nucleus expression relative to the membrane from cirrhosis to tumor. There was an association between IGF-1R nuclear expression in HCC and the moderate/poor grade of histologic differentiation (p < 0.001). However, long-term clinical outcomes were not associated with IGF-1R nuclear expression. Conclusion: The data presented here suggest the role of IGF-1R in HCC progression and carcinogenesis as its expression increases in the nucleus relative to the membrane, from cirrhosis to tumor, and it was associated with a poorer differentiated tumor grade. Further research is awaited to fully understand the mechanisms underlying this association. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Oncology is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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