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Phone: (843) 766-6635
Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Village Library
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Phone: (843) 884-9741
St. Paul's/Hollywood Library
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Phone: (843) 889-3300
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McClellanville Library
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Salivary IL‐33 and sST2 levels in relation to TLR2 rs111200466 polymorphism and periodontitis.
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- Author(s): Yilmaz, Mustafa; He, Qiushui; Demir, Esra; Teräsjärvi, Johanna; Gürsoy, Ulvi Kahraman
- Source:
Oral Diseases; May2024, Vol. 30 Issue 4, p2254-2261, 8p- Subject Terms:
- Source:
- Additional Information
- Abstract: Objectives: Toll‐like receptor‐2 (TLR2) signalling pathway is involved in the regulation of interleukin (IL)‐33 and its receptor suppression of tumorigenicity‐2 (ST2). This study aimed to compare salivary IL‐33 and soluble ST2 (sST2) levels of periodontitis patients with those of periodontally healthy individuals in relation to their TLR2 rs111200466 23‐bp insertion/deletion polymorphism within the promoter region. Materials and Methods: Unstimulated saliva samples were collected, and periodontal parameters were recorded from 35 periodontally healthy individuals and 44 periodontitis patients. Non‐surgical treatments were applied to periodontitis patients, and sample collections and clinical measurements were repeated 3 months following therapy. Salivary IL‐33 and sST2 levels were measured with enzyme‐linked immunosorbent assay kits, and TLR2 rs111200466 polymorphism was detected by polymerase chain reaction. Results: Elevated salivary IL‐33 (p = 0.007) and sST2 (p = 0.020) levels were observed in periodontitis patients, in comparison to controls. sST2 levels declined 3‐months following treatment (p < 0.001). Increased salivary IL‐33 and sST2 levels were found to be associated with periodontitis, with no significant relation to the TLR2 polymorphism. Conclusion: Periodontitis, but not TLR2 rs111200466 polymorphism, is associated with elevated salivary sST2 and possibly IL‐33 levels, and periodontal treatment is effective in reducing salivary sST2 levels. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Oral Diseases is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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