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Periodontitis‐induced neuroinflammation impacts dendritic spine immaturity and cognitive impairment.
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- Author(s): Xie, Changfu; Zhang, Qiuyang; Ye, Xinyi; Wu, Weiliang; Cheng, Xiaojuan; Ye, Xiaoan; Ruan, Jianyong; Pan, Xiaodong
- Source:
Oral Diseases; May2024, Vol. 30 Issue 4, p2558-2569, 12p- Subject Terms:
COGNITION disorder risk factors; FEAR; BONE resorption; COGNITIVE testing; RESEARCH funding; NEURONS; COMPUTED tomography; NEUROINFLAMMATION; REVERSE transcriptase polymerase chain reaction; DESCRIPTIVE statistics; MICE; IMMUNOHISTOCHEMISTRY; GENE expression; ANIMAL experimentation; CYTOKINES; HIPPOCAMPUS (Brain); PERIODONTITIS; ALVEOLAR process; INTERLEUKINS; TUMOR necrosis factors; DISEASE complications - Source:
- Additional Information
- Abstract: Objective: This study investigated the spinal changes in ligature‐induced periodontitis and the role of periodontitis in cognitive impairment. Methods: Twenty mice were randomized into the control and chronic periodontitis (CP) groups, with the latter receiving ligature‐induced periodontitis. Cognitive performance was assessed by fear conditioning test. Periodontal inflammation and alveolar bone resorption were evaluated by micro‐computed tomography and histopathology. The hippocampal microglial activation was evaluated by immunohistochemistry (IHC). The expressions of hippocampal cytokines (TNF‐α, iNOS, IL‐1β, IL‐4, IL‐10, and TREM2) were measured by reverse transcription–polymerase chain reaction. The morphology and density of the dendritic spines were determined by Golgi–Cox staining. Results: The CP mice reported significant inflammatory cell infiltration and alveolar bone resorption, with marked increases in cytokine levels (TNF‐α, iNOS, IL‐1β, and TREM2) in the brain. Moreover, the CP mice showed significantly reduced freezing to the conditioned stimulus in the cued and contextual tests, indicating impaired memory. Further analyses revealed, in the hippocampus of the CP mice, enhanced microglial activation, decreased dendritic spine density, and increased proportion of thin dendritic spines. Conclusions: Periodontitis‐induced neuroinflammation may impair the cognitive function by activating hippocampal microglia and inducing dendritic spine immaturity. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Oral Diseases is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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