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Phone: (843) 766-6635
Wando Mount Pleasant Library
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Village Library
9 a.m. - 6 p.m.
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St. Paul's/Hollywood Library
9 a.m. - 8 p.m.
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Otranto Road Library
9 a.m. - 8 p.m.
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Hurd/St. Andrews Library
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9 a.m. - 8 p.m.
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John L. Dart Library
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Phone: (843) 805-6930
Bees Ferry West Ashley Library
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Phone: (843) 805-6909
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Role of Diagnostic Laparoscopy During Pancreatic Cancer Surgery in the Modern Era.
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- Author(s): Chang, Jeremy1 (AUTHOR); Sherman, Scott K.1,2,3 (AUTHOR); De Andrade, James P.1,2,3 (AUTHOR); Hoshi, Hisakazu1,2,3 (AUTHOR); Howe, James R.1,2,3 (AUTHOR); Chan, Carlos H.F.1,2,3 (AUTHOR)
- Source:
Journal of Surgical Research. Jun2024, Vol. 298, p269-276. 8p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Despite improvements in preoperative image resolution, approximately 10% of curative-intent resection attempts for pancreatic ductal adenocarcinoma are aborted at the time of operation. To avoid nontherapeutic laparotomy, many surgeons perform intraoperative diagnostic laparoscopy (DL) to identify radiographically occult metastatic disease. There are no consensus guidelines regarding DL in pancreatic cancer. The goal of this study is to investigate the efficacy of same-procedure DL at avoiding nontherapeutic laparotomy. A single-institution retrospective review was performed from 2016 to 2022, identifying 196 patients with pancreatic ductal adenocarcinoma who were taken to the operating room for open curative-intent resection. Patient demographic, tumor characteristic, treatment, and outcome data were abstracted. Univariate and multivariate Cox hazard ratio analysis was performed to investigate risk factors for overall survival and recurrence-free survival. Number needed to treat (NNT) was calculated to identify number of DLs necessary to avoid one nontherapeutic laparotomy. Curative-intent resection was achieved in 161 (82.1%) patients. One hundred twenty six (64.0%) patients received DL prior to resection and DL identified metastatic disease in three (2.4%) patients with an NNT of 42. NNT of DL in a subgroup analysis performed on clinically high-risk patients (defined by preoperative or preneoadjuvant therapy carbohydrate antigen 19-9 > 500 U/mL) is 11. Receipt of DL did not prolong operative times in patients receiving pancreaticoduodenectomy when accounting for completed versus aborted resection. Although intraoperative DL is a short procedure with minimal morbidity, these data demonstrate that same-procedure DL has potential efficacy in avoiding nontherapeutic laparotomy only in a subgroup of clinically high-risk patients. Focus should remain on optimizing preoperative patient selection and further investigating novel diagnostic markers predictive of occult metastatic disease. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Surgical Research is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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