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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
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McClellanville Library
9 a.m. - 6 p.m.
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Keith Summey North Charleston Library
9 a.m. – 8 p.m.
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9 a.m. – 8 p.m.
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Hurd/St. Andrews Library
9 a.m. – 8 p.m.
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
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9 a.m. – 7 p.m.
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9 a.m. – 8 p.m.
Phone: (843) 805-6930
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Phone: (843) 805-6909
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Mediating Effect of White Blood Cells and Tobacco Exposure on Cervical Neoplasm Risk Among Taiwanese Women.
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- Author(s): Shih, Ya Wen; Chang, Ching Wen; Chang, Hui-Chen; Tsai, Jia Ruey; Wang, Wei-Jun; Fang, Hui Fen; Lin, Chia Ling; Rias, Yohanes Andy; Tsai, Hsiu Ting
- Source:
Biological Research for Nursing; Jul2024, Vol. 26 Issue 3, p380-389, 10p- Subject Terms:
LEUKOCYTE count; RISK assessment; TAIWANESE people; CERVICAL intraepithelial neoplasia; BIOPSY; CERVIX uteri tumors; WOMEN; VIRAL load; KILLER cells; T-test (Statistics); RESEARCH funding; SMOKING; QUESTIONNAIRES; LOGISTIC regression analysis; MULTIPLE regression analysis; INTERVIEWING; DNA; PAPILLOMAVIRUSES; DESCRIPTIVE statistics; RETROSPECTIVE studies; CHI-squared test; ODDS ratio; CASE-control method; PAP test; CONFIDENCE intervals; DATA analysis software; FACTOR analysis; PASSIVE smoking; DISEASE risk factors - Source:
- Additional Information
- Subject Terms:
- Abstract: Background: Both the high-risk human papillomavirus (HR-HPV) infection and tobacco exposure are significantly associated with cervical neoplasm risk. Immune cells play important roles in carcinogenesis. However, it is still unclear whether immune cells have a mediating effect on the HR-HPV infection and tobacco exposure with cervical neoplasm development. Aim: The aim of this study was to determine how the increased white blood cell (WBC) count affects the relationship between HR-HPV DNA load and tobacco exposure in the development of cervical neoplasia. Methods: A hospital-based case–control study design was conducted with a total of 108 cases of Taiwanese women with ≥ cervical intraepithelial neoplasia (CIN) I confirmed by biopsy, and 222 healthy Taiwanese female subjects with negative findings on a Pap smear were assigned to the control group. The study evaluated HR-HPV status and immune cell counts (WBCs, natural killer (NK) cells) and tobacco exposure by a self-construct questionnaire. Results: Both HR-HPV DNA load and tobacco exposure significantly independently increased cervical neoplasm risk (AORs: 1.28 and 1.42, respectively). Similar significant results were found for WBCs and NK cells, with respective AORs of 1.20 and 1.00. Moreover, increased WBCs (β = 0.04, 95% CI corrected: 0.01–0.07) and tobacco exposure (β = 0.02, 95% CI corrected: 0.01–0.04) mediated the relationship between the high-risk HPV DNA load and cervical neoplasm risk. Conclusions: Elevated WBC count acts as both predictor and mediator in cervical neoplasm development linked to HR-HPV DNA load. Monitoring and maintaining WBC levels within the normal range could be a preventive strategy for cervical neoplasm development. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Biological Research for Nursing is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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