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Acute and long-term outcomes of SARS-CoV-2 infection in school-aged children in England: Study protocol for the joint analysis of the COVID-19 schools infection survey (SIS) and the COVID-19 mapping and mitigation in schools (CoMMinS) study.
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- Author(s): Looker, Katharine J.1,2 (AUTHOR) .; McClenaghan, Elliot3 (AUTHOR); Judd, Alison4 (AUTHOR); Pierotti, Livia1,2,5 (AUTHOR); Downing, Harriet1,2 (AUTHOR); Phelan, Jody6 (AUTHOR); Warren-Gash, Charlotte7 (AUTHOR); Ngozi, Kalu3 (AUTHOR); Dawe, Fiona4 (AUTHOR); Relton, Caroline1,5,8,9 (AUTHOR); Christensen, Hannah1 (AUTHOR); Hay, Alastair D.1,2 (AUTHOR); Mangtani, Punam3 (AUTHOR); Nguipdop-Djomo, Patrick3 (AUTHOR); Denholm, Rachel1,2,5,10 (AUTHOR)
- Source:
PLoS ONE. 5/22/2024, Vol. 19 Issue 5, p1-13. 13p.- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: Background: The symptom profiles of acute SARS-CoV-2 infection and long-COVID in children and young people (CYP), risk factors, and associated healthcare needs, are poorly defined. The Schools Infection Survey 1 (SIS-1) was a nationwide study of SARS-CoV-2 infection in primary and secondary schools in England during the 2020/21 school year. The Covid-19 Mapping and Mitigation in Schools (CoMMinS) study was conducted in schools in the Bristol area over a similar period. Both studies conducted testing to identify current and previous SARS-CoV-2 infection, and recorded symptoms and school attendance. These research data have been linked to routine electronic health record (EHR) data. Aims: To better understand the short- and long-term consequences of SARS-CoV-2 infection, and their risk factors, in CYP. Methods: Retrospective cohort and nested case-control analyses will be conducted for SIS-1 and CoMMinS data linked to EHR data for the association between (1) acute symptomatic SARS-CoV-2 infection and risk factors; (2) SARS-CoV-2 infection and long-term effects on health: (a) persistent symptoms; (b) any new diagnosis; (c) a new prescription in primary care; (d) health service attendance; (e) a high rate of school absence. Results: Our study will improve understanding of long-COVID in CYP by characterising the trajectory of long-COVID in CYP in terms of things like symptoms and diagnoses of conditions. The research will inform which groups of CYP are more likely to get acute- and long-term outcomes of SARS-CoV-2 infection, and patterns of related healthcare-seeking behaviour, relevant for healthcare service planning. Digested information will be produced for affected families, doctors, schools, and the public, as appropriate. Conclusion: Linked SIS-1 and CoMMinS data represent a unique and rich resource for understanding the impact of SARS-CoV-2 infection on children's health, benefiting from enhanced SARS-CoV-2 testing and ability to assess a wide range of outcomes. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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