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Evaluation of Artemisia dubia folium extract-mediated immune efficacy through developing a murine model for acute and chronic stages of atopic dermatitis.
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- Author(s): Acharya, Manju; Gautam, Ravi; Yang, SuJeong; Jo, JiHun; Maharjan, Anju; Lee, DaEun; Ghimire, Narayan Prasad; Min, ByeongSun; Kim, ChangYul; Kim, HyoungAh; Heo, Yong
- Source:
Laboratory Animal Research; 4/7/2024, Vol. 40, p1-10, 10p- Subject Terms:
- Source:
- Additional Information
- Abstract: Background: Atopic dermatitis (AD) is a biphasic type of skin inflammation characterized by a predominance of type-2 (T
H 2) and type-1 (TH 1) helper T cell-biased immune responses at the acute and persistent chronic phases, respectively. The present study was aimed to evaluate the efficacy of Artemisia dubia folium extract (ADFE) on AD-like skin lesions through developing a murine model for acute and chronic stages of AD. To induce acute phase AD, the dorsal skin of BALB/c mice was sensitized twice a week with 1% 2, 4-dinitrochlorobenzene (DNCB), followed by challenge (twice) in the following week with 0.2% DNCB. To induce persistent chronic AD, some mice were challenged twice a week for 4 more weeks. After the second challenge, the dorsal skin was exposed to 3% ADFE (five times per week) for 2 weeks (acute phase) or 4 weeks (persistent chronic phase). Results: The paradigm of TH 2 or TH 1 predominance at the acute and chronic phase, respectively, was observed in this mouse model. During the acute phase, we observed an increased IL-4/IFN-γ ratio in splenic culture supernatants, an increased IgG1/IgG2a ratio in serum, and elevated serum IgE levels; however, the skew toward TH 2 responses was diminished during the chronic stage. Compared with vehicle controls, ADFE reduced the IL-4/IFN-γ and IgG1/IgG2a ratios in acute AD, but both ratios increased during the chronic stage. Conclusions: Our results suggest that ADFE concomitantly suppresses the TH 2 predominant response in acute AD, as well as the TH 1 predominant response in chronic AD. Thus, ADFE is a candidate therapeutic for AD. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Laboratory Animal Research is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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