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Edgar Allan Poe/Sullivan's Island Library
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Wando Mount Pleasant Library
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Phone: (843) 884-9741
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Association Between Serum Amyloid A Expression and Disease Control after Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis With Nasal Polyps.
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- Author(s): Lu, Hangui; Liu, Haiyan; Wang, Kanghua; Shi, Jianbo; Sun, Yueqi
- Source:
ENT: Ear, Nose & Throat Journal. Jun2024, Vol. 103 Issue 6, pNP331-NP339. 9p. - Source:
- Additional Information
- Subject Terms: PARANASAL sinus surgery; PREDICTIVE tests; RECEIVER operating characteristic curves; RESEARCH funding; DISEASE management; ENZYME-linked immunosorbent assay; ACUTE phase proteins; ENDOSCOPIC surgery; SINUSITIS; SYMPTOMS; DESCRIPTIVE statistics; CHRONIC diseases; NASAL polyps; IMMUNOHISTOCHEMISTRY; AMYLOID; GENE expression profiling; BIOMARKERS; ENDOSCOPY; SENSITIVITY & specificity (Statistics); EOSINOPHILS
- Abstract: Objective: Our previous study revealed that serum amyloid A (SAA) levels in polyp tissues could serve as a biomarker for the prediction of corticosteroid insensitivity in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). However, their association with disease control status in the patients after endoscopic sinus surgery remains to be assessed. Methods: Polyp tissues and control uncinate process mucosa were collected from 48 patients with CRSwNP and 10 healthy control subjects. SAA expression was examined using immunohistochemistry and enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) curves were performed to determine the predictive value of SAA in nasal polyps. The clinical characteristics of 2 CRSwNP subtypes (SAAhigh and SAAlow) were evaluated. Results: The SAA expression levels in polyp tissues were significantly elevated both in non-eosinophilic and eosinophilic CRSwNP as compared to the healthy controls. In patients with CRSwNP, the tissue SAA level was significantly higher in the disease-controlled patients than those of the partly controlled and uncontrolled. ROC curve analysis revealed that a cut-off value of 114.9 ng/mL for the tissue SAA level predicted the patients with disease-controlled status with 93.33% sensitivity and 63.64% specificity (AUC =.8727, P <.001). Furthermore, The SAAhigh subgroup showed higher tissue eosinophil numbers and percentage of the disease-controlled patients compared to the SAAlow subgroup. Conclusions: Our findings suggest that measurements of SAA in polyp tissues may provide useful information for evaluating CRSwNP conditions, especially identifying the CRSwNP patients with disease-controlled status after endoscopic sinus surgery. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of ENT: Ear, Nose & Throat Journal is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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