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West Ashley Library
Closed for Staff Day
Phone: (843) 766-6635
Wando Mount Pleasant Library
Closed for Staff Day
Phone: (843) 805-6888
Village Library
Closed for Staff Day
Phone: (843) 884-9741
St. Paul's/Hollywood Library
Closed for Staff Day
Phone: (843) 889-3300
Otranto Road Library
Closed for Staff Day
Phone: (843) 572-4094
Mt. Pleasant Library
Closed for Staff Day
Phone: (843) 849-6161
McClellanville Library
Closed for Staff Day
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Keith Summey North Charleston Library
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John's Island Library
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Hurd/St. Andrews Library
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Folly Beach Library
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Baxter-Patrick James Island
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Main Library
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Bees Ferry West Ashley Library
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Application of blinatumomab, a bispecific anti-CD3/CD19 T-cell engager, in treating severe systemic sclerosis: A case study.
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- Author(s): Subklewe, Marion1,2,3 (AUTHOR) ; Magno, Giulia1 (AUTHOR) ; Gebhardt, Christina1,4 (AUTHOR) ; Bücklein, Veit1,2,3 (AUTHOR) ; Szelinski, Franziska5 (AUTHOR) ; Arévalo, Héctor Julián Rincón5 (AUTHOR) ; Hänel, Gerulf2 (AUTHOR) ; Dörner, Thomas5 (AUTHOR) ; Zugmaier, Gerhard1,6 (AUTHOR) ; von Bergwelt-Baildon, Michael1,3 (AUTHOR) ; Skapenko, Alla1,4 (AUTHOR) ; Schulze-Koops, Hendrik1,4 (AUTHOR)
- Source:
European Journal of Cancer. Jun2024, Vol. 204, pN.PAG-N.PAG. 1p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Systemic sclerosis, a severe inflammatory autoimmune disease, shares a common thread with cancer through the underlying mechanism of inflammation. This inflammatory milieu not only drives the immune dysregulation characteristic of autoimmune diseases but also plays a pivotal role in the pathogenesis of cancer. Among the cellular components involved, B cells have emerged as key players in hematologic tumor and autoimmune disease, contributing to immune dysregulation and persistent tissue fibrosis in systemic sclerosis, as well as tumor progression and immune evasion in cancer. Consequently, novel therapeutic strategies targeting B cells hold promise in both conditions. Recent exploration of CD19 CAR T cells in severe systemic sclerosis patients has shown great potential, but also introduced possible risks and drawbacks associated with viral vectors, prolonged CAR T cell persistence, lengthy production timelines, high costs, and the necessity of conditioning patients with organotoxic and fertility-damaging chemotherapy. Given these challenges, alternative CD19-depleting approaches are of high interest for managing severe systemic autoimmune diseases. Here, we present the pioneering use of blinatumomab, a bispecific anti-CD3/anti-CD19 T cell engager in a patient with progressive, severe systemic sclerosis, offering a promising alternative for such challenging cases. • Autoimmune diseases share a common thread with cancer by underlying inflammation. • Novel therapeutic strategies targeting B cells hold promise in both conditions. • Blinatumomab is a bispecific T cell engager used in lymphoblastic B cell leukemia. • Systemic sclerosis is an autoimmune disease with causative B cell abnormalities. • We here report the first successful use of blinatumomab in systemic sclerosis. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of European Journal of Cancer is the property of Pergamon Press - An Imprint of Elsevier Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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