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In vitro and in vivo evaluation of the antitrypanosomal activity of fractions of Holarrhena africana.
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- Author(s): Nwodo NJ;Nwodo NJ; Brun R; Osadebe PO
- Source:
Journal of ethnopharmacology [J Ethnopharmacol] 2007 Sep 25; Vol. 113 (3), pp. 556-9. Date of Electronic Publication: 2007 Jul 22.
- Publication Type:
Journal Article
- Language:
English
- Additional Information
- Source:
Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0378-8741 (Print) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE
- Publication Information:
Publication: Limerick : Elsevier Sequoia
Original Publication: Lausanne, Elsevier Sequoia.
- Subject Terms:
- Abstract:
The aqueous extract of young leaves of Holarrhena africana, a plant used in the Nigerian traditional medicine, exhibited good activity against Trypanosoma brucei spp. The extract was fractionated and eight fractions were obtained. One fraction designated as HaF(5) showed in vitro activity against Trypanosoma brucei rhodesiense with an IC(50) value of 0.785 microg/mg and no overt cytotoxicity against L-6 cells. Fraction HaF(5) was tested in vivo at two doses and found to exhibit in vivo efficacy in Trypanosoma brucei brucei infected mice leading to a complete disappearance of parasitaemia followed by a relapse.
- Accession Number:
0 (Plant Extracts)
0 (Trypanocidal Agents)
- Publication Date:
Date Created: 20070831 Date Completed: 20080131 Latest Revision: 20070910
- Publication Date:
20250114
- Accession Number:
10.1016/j.jep.2007.07.018
- Accession Number:
17728085
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