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Folly Beach Library
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Wando Mount Pleasant Library
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Digoxin is Not Related to Mortality in Patients with Heart Failure: Results from the SELFIE-TR Registry.
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- Author(s): Çetin Güvenç, Rengin; Güvenç, Tolga Sinan; Çağlar, Mert Efe; Al Arfaj, Abdullah Ayar; Behrad, Ailin; Yılmaz, Mehmet Birhan
- Source:
American Journal of Cardiovascular Drugs; May2024, Vol. 24 Issue 3, p399-408, 10p- Subject Terms:
MORTALITY; ACADEMIC medical centers; T-test (Statistics); SCIENTIFIC observation; FUNCTIONAL assessment; HEART failure; RETROSPECTIVE studies; MULTIVARIATE analysis; MANN Whitney U Test; DESCRIPTIVE statistics; LOG-rank test; KAPLAN-Meier estimator; ODDS ratio; DIGOXIN; DATA analysis software; CONFIDENCE intervals; ECHOCARDIOGRAPHY; PROPORTIONAL hazards models; SYMPTOMS - Source:
- Additional Information
- Subject Terms:
- Abstract: Aims: Digoxin has been used in the treatment for heart failure for centuries, but the role of this drug in the modern era is controversial. A particular concern is the recent observational findings suggesting an increase in all-cause mortality with digoxin, although such observations suffer from biased results since these studies usually do not provide adequate compensation for the severity of disease. Using a nationwide registry database, we aimed to investigate whether digoxin is associated with 1-year all-cause mortality in patients with heart failure irrespective of phenotype. Methods: A total of 1014 out of 1054 patients in the registry, of whom 110 patients were on digoxin, were included in the study. Multivariable adjustments were done and propensity scores were calculated for various prognostic indicators, including signs and symptoms of heart failure and functional capacity. Crude mortality, mortality adjusted for covariates, mortality in the propensity score-matched cohort, and Bayesian factors (BFs) were analyzed. Results: Crude 1-year mortality rate did not differ between patients on and off digoxin (17.3% vs 20.1%, log-rank p = 0.46), and digoxin was not related to mortality following multivariable adjustment (hazard ratio 0.87, 95% confidence interval 0.539–1.402, p = 0.57). Similarly, all-cause mortality was similar in 220 propensity-score adjusted patients (17.3% vs 20.0%, log-rank p = 0.55). On Bayesian analyses, there was moderate to strong evidence suggesting a lack of difference between in unmatched cohort (BF
10 0.091) and weak-to-moderate evidence in the matched cohort (BF10 0.296). Conclusions: In this nationwide cohort, we did not find any evidence for an increased 1-year mortality in heart failure patients on digoxin. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of American Journal of Cardiovascular Drugs is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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