Response to Drs de Grooth and Parienti.

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  • Additional Information
    • Subject Terms:
      COVID-19; NATURAL history; SARS-CoV-2; COVID-19 treatment
    • Abstract:
      The article is a response to a letter from Drs de Grooth and Parienti regarding a trial-level surrogacy analysis. The authors explain that they were unable to reanalyze their study to compare results with the letter's suggestions due to a lack of data. However, they highlight the beneficial effects of a specific treatment in lowering RNA levels and reducing hospitalization/death. The authors also discuss the value of meta-regression analysis in evaluating treatment effectiveness and suggest the need for comprehensive trial identification and access to participant-level data in future pandemics. [Extracted from the article]
    • Abstract:
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