Clinical Characteristics of Chronic Nonbacterial Osteomyelitis Can Predict Therapy Needs Over Time.

A recent study presented at the Childhood Arthritis and Rheumatology Research Alliance's annual scientific meeting found that children with chronic nonbacterial osteomyelitis (CNO) who had symmetric bone lesions or multiple affected body regions were more likely to require second-line treatment. CNO is an auto-inflammatory condition that causes sterile inflammatory bone lesions, primarily in skeletally immature individuals. The study also revealed that patients with unifocal disease at diagnosis required fewer days of nonsteroidal anti-inflammatory drug (NSAID) monotherapy compared to those with multifocal disease. The researchers emphasized the importance of prompt and effective treatment for CNO, as delays in diagnosis are common. However, they noted that there is still uncertainty regarding which patients will respond to NSAIDs and which will require second-line treatment. The study's findings can be helpful for counseling patients and families, particularly in determining when to initiate second-line therapy if NSAID monotherapy is ineffective. The study was limited by its retrospective nature and missing data for some patients. [Extracted from the article]

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