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West Ashley Library
9 a.m. - 6 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. - 6 p.m.
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Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 6 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 6 p.m.
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9 a.m. - 6 p.m.
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McClellanville Library
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Keith Summey North Charleston Library
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Hurd/St. Andrews Library
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Minimal Inhibitory Concentrations Of Azithromycin In Typhoidal Salmonella Isolated In Tertiary Care Setting.
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- Author(s): Tariq, Anam (AUTHOR); Mirza, Irfan Ali (AUTHOR); Fahim, Qanita (AUTHOR); Bashir, Ayesha (AUTHOR); Hussain, Shafqat (AUTHOR); Hussain, Chahat (AUTHOR)
- Source:
Pakistan Armed Forces Medical Journal. 4/30/2024, Vol. 74 Issue 2, p265-265. 1p.- Subject Terms:
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- Additional Information
- Subject Terms:
- Abstract: Objective: To determine the variations in minimal inhibitory concentrations (MIC) of Azithromycin amongst Salmonella typhi isolates. Study Design: Cross-sectional study. Place and Duration of Study: Department of Microbiology, Combined Military Hospital, Lahore Pakistan, from Jan to Dec 2020. Methodology: Three hundred and eighty-four samples yielding the growth of Salmonella typhi were processed. Antibiotic susceptibility testing was done using the Kirby-Bauer Disk Diffusion technique, and the MIC of Azithromycin was determined using the E-strip method. Clinical and Laboratory Standards Institute (CLSI) recommended that MIC breakpoints be used for susceptibility testing of Azithromycin. Results: Of 384 tested isolates, 103(26.8%) were multidrug-resistant (MDR). Resistance to Ciprofloxacin was as high as 367(95.6%) isolates, whereas extensively drug-resistant (XDR) isolates were calculated to be 204(53.1%). No resistance against Azithromycin was observed. All the isolates were in the susceptible MIC range of 0.5 and 8 µg/ml. The lowest MIC observed was 0.5 µg/ml by 12(5%) of the isolates. The highest MIC value of 8 µg/ml was observed in 6(1.5%) isolates, all of which were XDR. 231(60.2%) isolates had one µg/ml MIC, followed by MIC 4 µg/ml of 72(18.8%) isolates. The mean MIC value of all the isolates was calculated to be 1.82±1.3µg/ml. Conclusion: The rise in XDR Salmonella typhi could lead to Azithromycin resistance. Antimicrobial stewardship is of prime importance, and Azithromycin MICs should be reported to keep the trends in check. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Pakistan Armed Forces Medical Journal is the property of Knowledge Bylanes and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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