Insufficient non-REM sleep intensity in narcolepsy-cataplexy.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Oxford University Press Country of Publication: United States NLM ID: 7809084 Publication Model: Print Cited Medium: Print ISSN: 0161-8105 (Print) Linking ISSN: 01618105 NLM ISO Abbreviation: Sleep Subsets: MEDLINE
    • Publication Information:
      Publication: 2017- : New York : Oxford University Press
      Original Publication: New York, Raven Press.
    • Subject Terms:
      Cataplexy/*diagnosis ; Narcolepsy/*diagnosis ; Sleep Deprivation/*diagnosis ; Sleep Stages/*physiology; Adolescent ; Adult ; Beta Rhythm ; Cataplexy/physiopathology ; Cerebral Cortex/physiopathology ; Delta Rhythm ; Female ; Humans ; Male ; Narcolepsy/physiopathology ; Polysomnography ; Reference Values ; Sleep Deprivation/physiopathology
    • Abstract:
      Study Objectives: To compare electroencephalogram (EEG) dynamics during nocturnal sleep in patients with narcolepsy-cataplexy and healthy controls. Fragmented nocturnal sleep is a prominent feature and contributes to excessive daytime sleepiness in narcolepsy-cataplexy. Only 3 studies have addressed changes in homeostatic sleep regulation as a possible mechanism underlying nocturnal sleep fragmentation in narcolepsy-cataplexy.
      Design, Setting and Participants: Baseline sleep of 11 drug-naive patients with narcolepsy-cataplexy (19-37 years) and 11 matched controls (18-41 years) was polysomnographically recorded. The EEG was subjected to spectral analysis.
      Interventions: None, baseline condition.
      Measurements and Results: All patients with narcolepsy-cataplexy but no control subjects showed a sleep-onset rapid eye movement (REM) episode. Non-REM (NREM)-REM sleep cycles were longer in patients with narcolepsy-cataplexy than in controls (P = 0.04). Mean slow-wave activity declined in both groups across the first 3 NREM sleep episodes (P<0.001). The rate of decline, however, appeared to be steeper in patients with narcolepsy-cataplexy (time constant: narcolepsy-cataplexy 51.1 +/- 23.8 minutes [mean +/- SEM], 95% confidence interval [CI]: 33.4-108.8 minutes) than in controls (169.4 +/- 81.5 minutes, 95% CI: 110.9-357.6 minutes) as concluded from nonoverlapping 95% confidence interval of the time constants. The steeper decline of SWA in narcolepsy-cataplexy compared to controls was related to an impaired build-up of slow-wave activity in the second cycle. Sleep in the second cycle was interrupted in patients with narcolepsy-cataplexy, when compared with controls, by an increased number (P = 0.01) and longer duration (P = 0.01) of short wake episodes.
      Conclusions: Insufficient NREM sleep intensity is associated with nonconsolidated nocturnal sleep in narcolepsy-cataplexy. The inability to consolidate sleep manifests itself when NREM sleep intensity has decayed below a certain level and is reflected in an altered time course of slow-wave activity across NREM sleep episodes.
    • References:
      Brain Res Bull. 1993;31(1-2):97-113. (PMID: 8453498)
      Electroencephalogr Clin Neurophysiol. 1995 Dec;95(6):414-25. (PMID: 8536570)
      Psychophysiology. 1979 May;16(3):283-91. (PMID: 220659)
      Sleep. 1986;9(1 Pt 2):205-15. (PMID: 3704444)
      J Sleep Res. 1993 Jun;2(2):70-81. (PMID: 10607074)
      Neurology. 1998 Feb;50(2 Suppl 1):S8-15. (PMID: 9484417)
      Electroencephalogr Clin Neurophysiol. 1992 Dec;83(6):339-49. (PMID: 1281079)
      Brain Res Bull. 1994;33(3):351-5. (PMID: 8293319)
      Sleep. 2005 Feb;28(2):239-47. (PMID: 16171249)
      J Sleep Res. 2003 Mar;12(1):63-71. (PMID: 12603788)
      J Neurosci. 2004 Jul 14;24(28):6291-300. (PMID: 15254084)
      Hum Neurobiol. 1982;1(3):195-204. (PMID: 7185792)
      Psychophysiology. 1968 Sep;5(2):142-8. (PMID: 4300800)
      J Sleep Res. 2004 Dec;13(4):395-406. (PMID: 15560774)
      Lancet. 2000 Jan 1;355(9197):39-40. (PMID: 10615891)
      Brain. 2002 Feb;125(Pt 2):373-83. (PMID: 11844737)
      Psychiatry Res. 1985 Nov;16(3):253-62. (PMID: 4089055)
      Sleep. 1999 Feb 1;22(1):77-87. (PMID: 9989368)
      Eur Arch Psychiatry Neurol Sci. 1987;236(6):323-8. (PMID: 3678290)
      Sleep. 1990 Apr;13(2):136-42. (PMID: 2330472)
      Brain Res. 1993 Oct 29;626(1-2):190-9. (PMID: 8281430)
      Ann Neurol. 1994 Jun;35(6):709-16. (PMID: 8210228)
      Sleep. 1991 Dec;14(6):540-5. (PMID: 1798888)
      Am J Physiol. 1996 Sep;271(3 Pt 2):R501-10. (PMID: 8853369)
      Sleep. 1986;9(1 Pt 2):162-6. (PMID: 3704437)
      Sleep Res Online. 1998;1(4):159-65. (PMID: 11382873)
      Neurophysiol Clin. 1996;26(1):51-9. (PMID: 8657098)
      Sleep. 1994 Dec;17(8 Suppl):S29-34. (PMID: 7701197)
    • Publication Date:
      Date Created: 20070819 Date Completed: 20070919 Latest Revision: 20240414
    • Publication Date:
      20240414
    • Accession Number:
      PMC1978383
    • Accession Number:
      10.1093/sleep/30.8.980
    • Accession Number:
      17702267