Activation patterns of Purkinje fibers during long-duration ventricular fibrillation in an isolated canine heart model.

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  • Additional Information
    • Source:
      Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0147763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4539 (Electronic) Linking ISSN: 00097322 NLM ISO Abbreviation: Circulation Subsets: MEDLINE
    • Publication Information:
      Publication: Hagerstown, MD : Lippincott Williams & Wilkins
      Original Publication: [Dallas, Tex., etc., American Heart Association, etc.]
    • Subject Terms:
      Disease Models, Animal*; Purkinje Fibers/*physiology ; Ventricular Fibrillation/*physiopathology; Action Potentials/physiology ; Animals ; Dogs ; Heart/physiology ; Purkinje Fibers/pathology
    • Abstract:
      Background: The roles of Purkinje fibers (PFs) and focal wave fronts, if any, in the maintenance of ventricular fibrillation (VF) are unknown. If PFs are involved in VF maintenance, it should be possible to map wave fronts propagating from PFs into the working ventricular myocardium during VF. If wave fronts ever arise focally during VF, it should be possible to map them appearing de novo.
      Methods and Results: Six canine hearts were isolated, and the left main coronary artery was cannulated and perfused. The left ventricular cavity was exposed, which allowed direct endocardial mapping of the anterior papillary muscle insertion. Nonperfused VF was induced, and 6 segments of data, each 5 seconds long, were analyzed during 10 minutes of VF. During 36 segments of data that were analyzed, 1018 PF or focal wave fronts of activation were identified. In 534 wave fronts, activation was mapped propagating from working ventricular myocardium to PF. In 142 wave fronts, activation was mapped propagating from PF to working ventricular myocardium. In 342 wave fronts, activation was mapped arising focally. More than 1 of these 3 patterns could occur in the same wave front.
      Conclusions: PFs are highly active throughout the first 10 minutes of VF. In addition to retrograde propagation from the working ventricular myocardium to PFs, antegrade propagation occurs from PFs to working ventricular myocardium, which suggests PFs are important in VF maintenance. Prior plunge needle recordings in dogs indicate activation propagates from the endocardium toward the epicardium after 1 minute of VF, which suggests that focal sites on the endocardium may represent foci and not breakthrough. If so, in addition to reentry, abnormal automaticity or triggered activity may also occur during VF.
    • Grant Information:
      HL28429 United States HL NHLBI NIH HHS; HL64184 United States HL NHLBI NIH HHS; HL66256 United States HL NHLBI NIH HHS; HL85370 United States HL NHLBI NIH HHS
    • Publication Date:
      Date Created: 20070819 Date Completed: 20071011 Latest Revision: 20071203
    • Publication Date:
      20221213
    • Accession Number:
      10.1161/CIRCULATIONAHA.107.699264
    • Accession Number:
      17698730