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Effects of Ocimum basilicum L. Extract on Hippocampal Oxidative Stress, Inflammation, and BDNF Expression in Amnesic Aged Rats.
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- Author(s): Beheshti, Farimah; Vakilian, Arefeh; Navari, Mohsen; Zare Moghaddam, Mostafa; Dinpanah, Hossein; Ahmadi-Soleimani, S. Mohammad
- Source:
Experimental Aging Research. Jul-Sep2024, Vol. 50 Issue 4, p443-458. 16p. - Source:
- Additional Information
- Subject Terms: SUPEROXIDE dismutase; BASIL; DATA analysis; OXIDATIVE stress; CATALASE; NEUROINFLAMMATION; PLANT extracts; GENE expression; RATS; BRAIN-derived neurotrophic factor; DRUG efficacy; ANIMAL experimentation; AGING; WESTERN immunoblotting; ANALYSIS of variance; STATISTICS; HIPPOCAMPUS (Brain); INFLAMMATION; AMNESIA; MEMORY disorders; INTERLEUKINS; MALONDIALDEHYDE
- Abstract: The present study was conducted to investigate the effects of Ocimum basilicum L. (OB) extract on learning and memory impairment in aged rats. Male rats were divided into the following experimental groups: Group 1 (control): including 2 months old rats, Group 2 (aged) including 2 years old rats, Groups 3–5 (aged-OB): including 2 years old rats received 50, 100, and 150 mg/kg OB for 8 weeks by oral gavage. Aging increased the delay to find the platform but, however, decreased the time spent in the target quadrant when tested by Morris water maze (MWM). Aging also reduced the latency to enter the dark chamber in the passive avoidance (PA) test compared to the control group. Moreover, interleukin-6 (IL-6) and malondialdehyde (MDA) levels were raised in the hippocampus and cortex of aged rats. In contrast, thiol levels and enzymatic activity of superoxide dismutase (SOD) and catalase (CAT) significantly reduced. In addition, aging significantly reduced BDNF expression. Finally, OB administration reversed the mentioned effects. The current research showed that OB administration improves learning/memory impairment induced by aging. It also found that this plant extract protects the brain tissues from oxidative damage and neuroinflammation. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Experimental Aging Research is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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