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The role of ethnicity and native-country income in multiple sclerosis: the Italian multicentre study (MS-MigIT).
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- Author(s): Bianchi, Alessia; Matranga, Domenica; Patti, Francesco; Maniscalco, Laura; Pilotto, Silvy; Di Filippo, Massimiliano; Zaffaroni, Mauro; Annovazzi, Pietro; Bertolotto, Antonio; Gasperini, Claudio; Quartuccio, Esmeralda; Centonze, Diego; Fantozzi, Roberta; Gajofatto, Alberto; Gobbin, Francesca; Landi, Doriana; Granella, Franco; Buccafusca, Maria; Marfia, Girolama Alessandra; Chisari, Clara
- Source:
Journal of Neurology; May2024, Vol. 271 Issue 5, p2182-2194, 13p- Subject Terms:
- Source:
- Additional Information
- Subject Terms:
- Abstract: Objective: Multiple sclerosis (MS) is a complex disorder in which environmental and genetic factors interact modifying disease risk and course. This multicentre, case–control study involving 18 Italian MS Centres investigated MS course by ethnicity and native-country economic status in foreign-born patients living in Italy. Methods: We identified 457 MS patients who migrated to Italy and 893 age- and sex-matched native-born Italian patients. In our population, 1225 (93.2%) subjects were White Europeans and White Northern Americans (WENA) and 89 (6.8%) patients were from other ethnical groups (OEG); 1109 (82.1%) patients were born in a high-income (HI) Country and 241 (17.9%) in a low-middle-income (LMI) Country. Medical records and patients interviews were used to collect demographic and disease data. Results: We included 1350 individuals (973 women and 377 men); mean (SD) age was 45.0 (11.7) years. At onset, 25.45% OEG patients vs 12.47% WENA (p = 0.039) had > 3 STIR spine lesions. At recruitment, the same group featured mean (SD) EDSS score of 2.85 (2.23) vs 2.64 (2.28) (p = 0.044) reached in 8.9 (9.0) vs 12.0 (9.0) years (p = 0.018) and underwent 1.10 (4.44) vs. 0.99 (0.40) annual MRI examinations (p = 0.035). At disease onset, patients from LMI countries had higher EDSS score than HI patients (2.40 (1.43) vs 1.99 (1.17); p = 0.032). Discussion: Our results suggested that both ethnicity and socio-economic status of native country shape MS presentation and course and should be considered for an appropriate management of patients. To the best of our knowledge, this is the first study reporting on the impact of ethnicity in MS at an individual level and beyond an ecological population-perspective. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Neurology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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