Role of Tula-Family Proteins in Cell Signaling and Activation: Advances and Challenges.

This article discusses the role of Tula-Family Proteins in cell signaling and activation. The Tula-Family Proteins, also known as UBASH3A and UBASH3B, are a relatively novel vertebrate gene/protein family that have been the subject of research for the past 20 years. Both UBASH3A and UBASH3B possess protein tyrosine phosphatase (PTP) activity and suppress protein tyrosine kinase (PTK)-dependent cell signaling. However, they also have distinct differences in substrate specificity, optimal conditions for PTP activity, and tissue expression. UBASH3A has been linked to autoimmune diseases, while UBASH3B appears to be involved in Behcet's disease. The article also discusses the conservation of the UBASH3 family in vertebrates and the unique UBASH3 family found in teleosts. Several papers published in this special issue further explore the role of UBASH3A/B proteins in immunity, autoimmune conditions, platelets, and individual development. The review articles highlight the challenges in understanding this family despite two decades of research. [Extracted from the article]

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