Current Status and Future Perspective in Glioma Invasion Research.

This document is an editorial from the journal "Brain Sciences" discussing the current status and future perspectives in glioma invasion research. The editorial highlights the need to better understand the molecular mechanisms underlying GBM invasion in order to develop effective treatment methods. It also provides an overview of several articles included in a special issue of the journal, which cover topics such as the role of the tumor microenvironment, in vivo invasion models, and imaging techniques for detecting nonenhancing tumors in GBM. The editorial emphasizes the importance of further research to translate these findings into clinically effective therapies against GBM invasion. The article discusses the molecular mechanisms and clinical challenges of glioma invasion, focusing on glioblastoma (GBM). The interactions between tumor cells and the tumor microenvironment (TME) play a critical role in tumor invasion. Hypoxia, or low oxygen levels, in the TME is known to modify cellular processes and promote GBM invasion. The article also highlights the importance of detecting and surgically resecting infiltrating tumor cells in order to improve prognosis for GBM patients. The use of imaging modalities such as Met-PET and fluorescence-guided surgery with 5-ALA are discussed as potential methods for detecting infiltrating tumor cells. The article concludes by emphasizing the need for further research to develop effective anti-invasion therapies for GBM. [Extracted from the article]

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