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Response and Outcomes of Maintenance Avelumab After Platinum-Based Chemotherapy (PBC) in Patients With Advanced Urothelial Carcinoma (aUC): "Real World" Experience.
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- Author(s): Bakaloudi, Dimitra Rafailia; Talukder, Rafee; Lin, Genevieve Ihsiu; Makrakis, Dimitrios; Diamantopoulos, Leonidas N.; Tripathi, Nishita; Agarwal, Neeraj; Zakopoulou, Roubini; Bamias, Aristotelis; Brown, Jason R.; Pinato, David J.; Korolewicz, James; Jindal, Tanya; Koshkin, Vadim S.; Murgić, Jure; Miletić, Marija; Frobe, Ana; Johnson, Jeffrey; Zakharia, Yousef; Drakaki, Alexandra
- Source:
Clinical Genitourinary Cancer; Oct2023, Vol. 21 Issue 5, p584-593, 10p- Subject Terms:
- Source:
- Additional Information
- Abstract: Based on JAVELINBladder100 trial, avelumab maintenance was approved for patients with advanced urothelial carcinoma (aUC) without progression on first-line platinum-based chemotherapy. We examined patient characteristics, prognostic factors and outcomes in patients who received avelumab switch maintenance in a "realworld" (outside trials) setting. Our results appear similar with those from the clinical trial and recent "real world" studies. Background: Platinum-based chemotherapy (PBC) followed by avelumab switch maintenance in nonprogressors is standard first line (1L) treatment for advanced urothelial carcinoma (aUC). We describe clinical features and outcomes in a "real-world' cohort treated with avelumab maintenance for aUC. Materials and Methods: This was a retrospective cohort study of patients (pts) who received 1L switch maintenance avelumab after no progression on PBC for aUC. We calculated progression-free survival (PFS) and overall survival (OS) from initiation of maintenance avelumab. We also described OS and PFS for specific subsets using Cox regression and observed response rate (ORR). Results: A total of 108 pts with aUC from 14 sites treated with maintenance avelumab were included. There was a median of 6 weeks1-30 from end of PBC to avelumab initiation; median follow-up time from avelumab initiation was 8.8 months (1-42.7). Median [m]PFS was 9.6 months (95%CI 7.5-12.1) and estimated 1-year OS was 72.5%. CR/PR (vs. SD) to 1L PBC (HR = 0.33, 95% CI 0.13-0.87) and ECOG PS 0 (vs. =1), (HR = 0.15, 95% CI 0.05-0.47) were associated with longer OS. The presence of liver metastases was associated with shorter PFS (HR = 2.32, 95% CI 1.17-4.59). ORR with avelumab maintenance was 28.7% (complete response 17.6%, partial response 11.1%), 29.6% stable disease, 26.9% progressive disease as best response (14.8% best response unknown). Conclusions: Results seem relatively consistent with findings from JAVELIN Bladder100 trial and recent "real wor ld" studies. Pr ior response to platinum-based chemotherapy, ECOG PS 0, and absence of liver metastases were favorable prognostic factors. Limitations include the retrospective design, lack of randomization and central scan review, and possible selection/confounding biases. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Clinical Genitourinary Cancer is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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