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Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
9 a.m. – 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
9 a.m. – 8 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 8 p.m.
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McClellanville Library
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Keith Summey North Charleston Library
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John's Island Library
9 a.m. – 8 p.m.
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Hurd/St. Andrews Library
9 a.m. – 8 p.m.
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Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
9 a.m. – 8 p.m.
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9 a.m. – 7 p.m.
Phone: (843) 722-7550
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Phone: (843) 805-6930
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Ginsenoside Rd Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Inflammation and Apoptosis through PI3K/Akt Signaling Pathway.
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- Author(s): Wang, Yuanping (AUTHOR); Zheng, Jiading (AUTHOR); Xiao, Xieyang (AUTHOR); Feng, Cailing (AUTHOR); Li, Yinghong (AUTHOR); Su, Hui (AUTHOR); Yuan, Ding (AUTHOR); Wang, Qinghai (AUTHOR); Huang, Peihong (AUTHOR); Jin, Lili (AUTHOR)
- Source:
American Journal of Chinese Medicine. 2024, Vol. 52 Issue 2, p433-451. 19p. - Source:
- Additional Information
- Subject Terms: INFLAMMATION prevention; IN vitro studies; MYOCARDIAL ischemia; MYOCARDIAL reperfusion complications; INTRAPERITONEAL injections; PENTOBARBITAL; STATISTICAL significance; RESEARCH funding; APOPTOSIS; PHARMACEUTICAL chemistry; ENZYME-linked immunosorbent assay; CELLULAR signal transduction; IN vivo studies; REVERSE transcriptase polymerase chain reaction; PLANT extracts; MICE; CELL culture; IMMUNOHISTOCHEMISTRY; GLYCOSIDES; DRUG efficacy; MYOCARDIUM; MOLECULAR structure; WESTERN immunoblotting; ONE-way analysis of variance; GINSENG; PHOSPHOTRANSFERASES; STAINS & staining (Microscopy); CELL survival; HEALTH outcome assessment; COMPARATIVE studies; TIME; ECHOCARDIOGRAPHY; HEART cells; TUMOR necrosis factors
- Abstract: Myocardial ischemia/reperfusion (I/R) injury is the leading cause of death worldwide. Ginsenoside Rd (GRd) has cardioprotective properties but its efficacy and mechanism of action in myocardial I/R injury have not been clarified. This study investigated GRd as a potent therapeutic agent for myocardial I/R injury. Oxygen-glucose deprivation and reperfusion (OGD/R) and left anterior descending (LAD) coronary artery ligation were used to establish a myocardial I/R injury model in vitro and in vivo. In vivo, GRd significantly reduced the myocardial infarct size and markers of myocardial injury and improved the cardiac function in myocardial I/R injury mice. In vitro, GRd enhanced cell viability and protected the H9c2 rat cardiomyoblast cell line from OGD-induced injury GRd. The network pharmacology analysis predicted 48 potential targets of GRd for the treatment of myocardial I/R injury. GO and KEGG enrichment analysis indicated that the cardioprotective effects of GRd were closely related to inflammation and apoptosis mediated by the PI3K/Akt signaling pathway. Furthermore, GRd alleviated inflammation and cardiomyocyte apoptosis in vivo and inhibited OGD/R-induced apoptosis and inflammation in cardiomyocytes. GRd also increased PI3K and Akt phosphorylation, suggesting activation of the PI3K/Akt pathway, whereas LY294002, a PI3K inhibitor, blocked the GRd-induced inhibition of OGD/R-induced apoptosis and inflammation in H9c2 cells. The therapeutic effect of GRd in vivo and in vitro against myocardial I/R injury was primarily dependent on PI3K/Akt pathway activation to inhibit inflammation and cardiomyocyte apoptosis. This study provides new evidence for the use of GRd as a cardiovascular drug. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of American Journal of Chinese Medicine is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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