[Human allogeneic cultured epidermis: medico-legal considerations].

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  • Additional Information
    • Transliterated Title:
      Epidermide umana coltivata allogenica: considerazioni medico-legali.
    • Source:
      Publisher: Casa Editrice Licinio Cappelli Country of Publication: Italy NLM ID: 0372343 Publication Model: Print Cited Medium: Print ISSN: 0003-469X (Print) Linking ISSN: 0003469X NLM ISO Abbreviation: Ann Ital Chir Subsets: MEDLINE
    • Publication Information:
      Original Publication: Bologna : Casa Editrice Licinio Cappelli
    • Subject Terms:
      Cells, Cultured* ; Keratinocytes*; Skin Transplantation/*legislation & jurisprudence; Burns/surgery ; Humans ; Italy ; Langerhans Cells ; Tissue Donors ; Transplantation, Homologous
    • Abstract:
      The possibility of cultivating in vitro human kerathinocytes has opened new prospectives in the surgical treatment of major burns and, generally, in patients with extensive skin loss (degloving, etc.). Epidermidal sheets, obtained in vitro, have been used initially, successfully, as autografts. Later, their peculiar immunological characteristic (absence of Langerhans cells expressing class II MHC antigens and inability of evocating omograft rejection) has allowed it's use as allograft without the need of resorting to treatment with immunosuppressive drugs. Medico-legal problems raised by the use of human epidermys cultivated as allograft are described hereafter.
    • Publication Date:
      Date Created: 19910701 Date Completed: 19920220 Latest Revision: 20061115
    • Publication Date:
      20221213
    • Accession Number:
      1768005