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First-in-Human Whole-Eye Transplantation: Ensuring an Ethical Approach to Surgical Innovation.
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- Author(s): Laspro, Matteo; Thys, Erika; Chaya, Bachar; Rodriguez, Eduardo D.; Kimberly, Laura L.
- Source:
American Journal of Bioethics; May2024, Vol. 24 Issue 5, p59-73, 15p- Subject Terms:
PREVENTION of surgical complications; EYE transplantation; PATIENT selection; FACIAL transplantation; RISK assessment; VISION disorders; TRANSPLANTATION of organs, tissues, etc.; DIFFUSION of innovations; PATIENTS; GROUP identity; IMMUNOSUPPRESSIVE agents; HOMOGRAFTS; BIOETHICS; ATTITUDE (Psychology); SURGICAL complications; QUALITY of life; SOCIAL support; SOCIAL stigma; DISEASE risk factors - Source:
- Additional Information
- Abstract: As innovations in the field of vascular composite allotransplantation (VCA) progress, whole-eye transplantation (WET) is poised to transition from non-human mammalian models to living human recipients. Present treatment options for vision loss are generally considered suboptimal, and attendant concerns ranging from aesthetics and prosthesis maintenance to social stigma may be mitigated by WET. Potential benefits to WET recipients may also include partial vision restoration, psychosocial benefits related to identity and social integration, improvements in physical comfort and function, and reduced surgical risk associated with a biologic eye compared to a prosthesis. Perioperative and postoperative risks of WET are expected to be comparable to those of facial transplantation (FT), and may be similarly mitigated by immunosuppressive protocols, adequate psychosocial support, and a thorough selection process for both the recipient and donor. To minimize the risks associated with immunosuppressive medications, the first attempts in human recipients will likely be performed in conjunction with a FT. If first-in-human attempts at combined FT-WET prove successful and the biologic eye survives, this opens the door for further advancement in the field of vision restoration by means of a viable surgical option. This analysis integrates recent innovations in WET research with the existing discourse on the ethics of surgical innovation and offers preliminary guidance to VCA programs considering undertaking WET in human recipients. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of American Journal of Bioethics is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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