Effects of antisense oligonucleotides to mRNA for the early gene zif268 on the mechanisms of synapse-specific plasticity.

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  • Author(s): Nikitin VP;Nikitin VP; Kozyrev SA
  • Source:
    Neuroscience and behavioral physiology [Neurosci Behav Physiol] 2007 Jul; Vol. 37 (6), pp. 607-12.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Springer Country of Publication: United States NLM ID: 0330471 Publication Model: Print Cited Medium: Print ISSN: 0097-0549 (Print) Linking ISSN: 00970549 NLM ISO Abbreviation: Neurosci Behav Physiol Subsets: MEDLINE
    • Publication Information:
      Publication: <2005- > : New York : Springer
      Original Publication: Washington, Scripta Pub. Corp.
    • Subject Terms:
      Early Growth Response Protein 1/*antagonists & inhibitors ; Neuronal Plasticity/*drug effects ; Oligodeoxyribonucleotides, Antisense/*pharmacology ; Synapses/*drug effects; Animals ; Behavior, Animal ; Dose-Response Relationship, Drug ; Early Growth Response Protein 1/genetics ; Early Growth Response Protein 1/physiology ; Head/innervation ; Head/physiology ; Helix, Snails ; Muscle Relaxants, Central/pharmacology ; Neuronal Plasticity/physiology ; Neurons/drug effects ; Neurons/physiology ; Physical Stimulation/methods ; Quinine/pharmacology ; RNA, Messenger/antagonists & inhibitors ; Repression-Sensitization ; Synapses/physiology
    • Abstract:
      Acquisition of nociceptive sensitization in common snails was accompanied by long-term facilitation of the responses of defensive behavior command neuron LPl1 to sensory stimulation of chemoreceptors on the head and mechanoreceptors on the head and foot. Acquisition of sensitization during intracellular administration of antisense oligonucleotides to mRNA encoding the early gene zif268 showed suppression of synaptic facilitation in the responses of neuron LPl1 to tactile and chemical stimulation of the snail's head. Synaptic facilitation in the responses to tactile stimulation of the foot developed as in neurons of control sensitized animals. These results suggest that the early gene zif268 is selectively involved in the mechanisms of the specific regulation of the synaptic inputs of neuron LPl1 from sensory receptors on the snail's head.
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    • Accession Number:
      0 (Early Growth Response Protein 1)
      0 (Egr1 protein, rat)
      0 (Muscle Relaxants, Central)
      0 (Oligodeoxyribonucleotides, Antisense)
      0 (RNA, Messenger)
      A7V27PHC7A (Quinine)
    • Publication Date:
      Date Created: 20070728 Date Completed: 20071026 Latest Revision: 20191210
    • Publication Date:
      20231215
    • Accession Number:
      10.1007/s11055-007-0059-7
    • Accession Number:
      17657432