Glucose-dependent insulinotropic polypeptide receptor systems in the hypothalamus and the brainstem regulate feeding and weight through distinct pathways.

A commentary published in the Journal of Diabetes Investigation discusses the role of GIPR neurons in the hypothalamus and brainstem in regulating feeding and weight. The study found that activating these neurons resulted in different feeding and behavior responses. The study suggests that these pathways work together to reduce feeding and bodyweight. The article also explores the effects of GLP-1RA and GIPRA on bodyweight and food intake in mice, and suggests that GIPRA may have a role in controlling feeding and bodyweight. However, more research is needed to understand the safety and potential side effects of GIPR/GLP-1R coagonism. [Extracted from the article]

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