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West Ashley Library
Closed for Staff Day
Phone: (843) 766-6635
Wando Mount Pleasant Library
Closed for Staff Day
Phone: (843) 805-6888
Village Library
Closed for Staff Day
Phone: (843) 884-9741
St. Paul's/Hollywood Library
Closed for Staff Day
Phone: (843) 889-3300
Otranto Road Library
Closed for Staff Day
Phone: (843) 572-4094
Mt. Pleasant Library
Closed for Staff Day
Phone: (843) 849-6161
McClellanville Library
Closed for Staff Day
Phone: (843) 887-3699
Keith Summey North Charleston Library
Closed for Staff Day
Phone: (843) 744-2489
John's Island Library
Closed for Staff Day
Phone: (843) 559-1945
Hurd/St. Andrews Library
Closed for Staff Day
Phone: (843) 766-2546
Folly Beach Library
Closed for Staff Day
Phone: (843) 588-2001
Dorchester Road Library
Closed for Staff Day
Phone: (843) 552-6466
John L. Dart Library
Closed for Staff Day
Phone: (843) 722-7550
Baxter-Patrick James Island
Closed for Staff Day
Phone: (843) 795-6679
Main Library
Closed for Staff Day
Phone: (843) 805-6930
Bees Ferry West Ashley Library
Closed for Staff Day
Phone: (843) 805-6892
Miss Jane's Building (Edisto Library Temporary Location)
Closed
Phone: (843) 869-2355
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Closed for renovations
Phone: (843) 883-3914
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
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Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models.
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- Author(s): Wang, Ruonan; Kang, Shijia; Zhao, Zirui; Jin, Lingling; Cui, Xiaolin; Chen, Lili; Schachner, Melitta; Li, Sheng; Guo, Yanjie; Zhao, Jie
- Source:
International Journal of Molecular Sciences; Mar2024, Vol. 25 Issue 6, p3408, 13p- Subject Terms:
- Source:
- Additional Information
- Abstract: Alzheimer's disease (AD) is the most common progressive neurodegenerative disease. The accumulation of amyloid-beta (Aβ) plaques is a distinctive pathological feature of AD patients. The aims of this study were to evaluate the therapeutic effect of chicoric acid (CA) on AD models and to explore its underlying mechanisms. APPswe/Ind SH-SY5Y cells and 5xFAD mice were treated with CA. Soluble Aβ1–42 and Aβ plaque levels were analyzed by ELISA and immunohistochemistry, respectively. Transcriptome sequencing was used to compare the changes in hippocampal gene expression profiles among the 5xFAD mouse groups. The specific gene expression levels were quantified by qRT-PCR and Western blot analysis. It was found that CA treatment reduced the Aβ1–42 levels in the APPswe/Ind cells and 5xFAD mice. It also reduced the Aβ plaque levels as well as the APP and BACE1 levels. Transcriptome analysis showed that CA affected the synaptic-plasticity-related genes in the 5xFAD mice. The levels of L1CAM, PSD-95 and synaptophysin were increased in the APPswe/Ind SH-SY5Y cells and 5xFAD mice treated with CA, which could be inhibited by administering siRNA-L1CAM to the CA-treated APPswe/Ind SH-SY5Y cells. In summary, CA reduced Aβ levels and increased the expression levels of synaptic-function-related markers via L1CAM in AD models. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of International Journal of Molecular Sciences is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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