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Folly Beach Library
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Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
West Ashley Library
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Phone: (843) 766-6635
Wando Mount Pleasant Library
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Phone: (843) 805-6888
Village Library
9 a.m. – 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. – 8 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. – 8 p.m.
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9 a.m. – 8 p.m.
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McClellanville Library
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Keith Summey North Charleston Library
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Hurd/St. Andrews Library
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Phone: (843) 805-6930
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Determinants of Achieving Serum Urate Goal with Treat‐to‐Target Urate‐Lowering Therapy in Gout.
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- Author(s): Helget, Lindsay N.; O'Dell, James R.; Newcomb, Jeff A.; Androsenko, Maria; Brophy, Mary T.; Davis‐Karim, Anne; England, Bryant R.; Ferguson, Ryan; Pillinger, Michael H.; Neogi, Tuhina; Palevsky, Paul M.; Wu, Hongsheng; Kramer, Bridget; Mikuls, Ted R.
- Source:
Arthritis & Rheumatology; Apr2024, Vol. 76 Issue 4, p638-646, 9p- Subject Terms:
PATIENT compliance; SOCIAL determinants of health; BODY mass index; RESEARCH funding; PREDICTION models; ENZYME inhibitors; MULTIPLE regression analysis; GOAL (Psychology); RANDOMIZED controlled trials; DIURETICS; MULTIVARIATE analysis; DESCRIPTIVE statistics; GOUT suppressants; ODDS ratio; RACE; GOUT; ALLOPURINOL; OXIDOREDUCTASES; URIC acid; QUALITY of life; COMPARATIVE studies; SOCIODEMOGRAPHIC factors; DRUGS; INDIVIDUALIZED medicine; COMORBIDITY; EDUCATIONAL attainment; CHEMICAL inhibitors - Source:
- Additional Information
- Abstract: Objective: Using trial data comparing treat‐to‐target allopurinol and febuxostat in gout, we examined participant characteristics associated with serum urate (SU) goal achievement. Methods: Participants with gout and SU ≥6.8 mg/dL were randomized to allopurinol or febuxostat, titrated during weeks 0 to 24, and maintained weeks 25 to 48. Participants were considered to achieve SU goal if the mean SU from weeks 36, 42, and 48 was <6.0 mg/dL or <5 mg/dL if tophi were present. Possible determinants of treatment response were preselected and included sociodemographics, comorbidities, diuretic use, health‐related quality of life (HRQoL), body mass index, and gout measures. Determinants of SU response were assessed using multivariable logistic regression with additional analyses to account for treatment adherence. Results: Of 764 study participants completing week 48, 618 (81%) achieved SU goal. After multivariable adjustment, factors associated with a greater likelihood of SU goal achievement included older age (adjusted odds ratio [aOR] 1.40 per 10 years), higher education (aOR 2.02), and better HRQoL (aOR 1.17 per 0.1 unit). Factors associated with a lower odds of SU goal achievement included non‐White race (aORs 0.32–0.47), higher baseline SU (aOR 0.83 per 1 mg/dL), presence of tophi (aOR 0.29), and the use of diuretics (aOR 0.52). Comorbidities including chronic kidney disease, hypertension, diabetes, and cardiovascular disease were not associated with SU goal achievement. Results were not meaningfully changed in analyses accounting for adherence. Conclusions: Several patient‐level factors were predictive of SU goal achievement among patients with gout who received treat‐to‐target urate‐lowering therapy (ULT). Approaches that accurately predict individual responses to treat‐to‐target ULT hold promise in facilitating personalized management and improving outcomes in patients with gout. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Arthritis & Rheumatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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