New Antiarrhythmic Agents Study Findings Reported from Institute of Bioorganic Chemistry (Polyelectrolyte Microcapsules: An Extended Release System for the Antiarrhythmic Complex of Allapinin with Glycyrrhizic Acid Salt).

Researchers from the Institute of Bioorganic Chemistry in Tashkent, Uzbekistan have conducted a study on the encapsulation of the antiarrhythmic complex of allapinin with glycyrrhizic acid salt (Al:MASGA) in polyelectrolyte microcapsules (PMC) for extended release. Allapinin is an antiarrhythmic drug that can be used to prevent and treat various types of arrhythmias, but it has high toxicity and side effects. The researchers found that the sorption method facilitated the encapsulation of up to 80% of the original substance content in the PMC. The release of the encapsulated Al:MASGA was independent of the substance content in the capsules, but a decrease in the rate of drug release was observed at pH 5. This study provides insights into the development of a less toxic and more effective antiarrhythmic drug delivery system. [Extracted from the article]

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