Impact of anxiety disorder comorbidity on quality of life in euthymic bipolar disorder patients: differences between bipolar I and II subtypes.

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  • Author(s): Albert U;Albert U; Rosso G; Maina G; Bogetto F
  • Source:
    Journal of affective disorders [J Affect Disord] 2008 Jan; Vol. 105 (1-3), pp. 297-303. Date of Electronic Publication: 2007 Jul 06.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0165-0327 (Print) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.
    • Subject Terms:
      Anxiety Disorders/*epidemiology ; Bipolar Disorder/*epidemiology ; Dysthymic Disorder/*epidemiology ; Quality of Life/*psychology; Anxiety Disorders/diagnosis ; Bipolar Disorder/diagnosis ; Comorbidity ; Cross-Sectional Studies ; Demography ; Dysthymic Disorder/diagnosis ; Female ; Health Status ; Humans ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Severity of Illness Index ; Surveys and Questionnaires
    • Abstract:
      Background: Few studies investigated the impact of anxiety disorder comorbidity on health-related quality of life (HRQoL) of bipolar patients and none examined bipolar subtypes differences. The aim of the study was 1) to determine comorbidity rates for anxiety disorders in euthymic bipolar subjects, comparing bipolar type I and II disorders (BDI and BDII), and 2) to compare within each group HRQoL measures in subjects with and without anxiety comorbidity.
      Methods: Comorbidity was evaluated through the SCID-I; HRQoL was assessed using the 36-Item Short-Form Health Survey (SF-36). All subjects were euthymic since at least 2 months, as confirmed by a HAM-D <8 and a YMRS <6. A comparison was made for SF-36 scores between subjects (all bipolars, BDI and BDII) with and without anxiety disorders.
      Results: 105 patients were enrolled: 44 with BDI and 61 with BDII. Current and lifetime anxiety disorders comorbidities were 32.4% and 41.0% for all bipolars, 31.8% and 40.9% for BDI and 32.8% and 41.0% for BDII. BDI patients differed in several SF-36 domains from BDII subjects, which reported a poorer HRQoL. A current and lifetime comorbid anxiety disorder was associated with a poorer HRQoL considering all bipolars; when examining separately BDI and II subjects, however, the deleterious effect was restricted to BDI patients.
      Limitations: The cross-sectional assessment of HRQoL, the generic instrument used (SF-36) and the small sample size.
      Conclusions: Our study confirms the high comorbidity rates for anxiety disorders in bipolar subjects and provides evidence that anxiety comorbidity impacts HRQoL in subjects with BDI and not BDII.
    • Publication Date:
      Date Created: 20070710 Date Completed: 20080430 Latest Revision: 20151119
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.jad.2007.05.020
    • Accession Number:
      17617468