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9 a.m. - 7 p.m.
Phone: (843) 766-6635
Wando Mount Pleasant Library
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Village Library
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St. Paul's/Hollywood Library
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Otranto Road Library
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McClellanville Library
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Non-criteria antiphospholipid antibodies and calprotectin as potential biomarkers in pediatric antiphospholipid syndrome.
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- Author(s): Sloan, Elizabeth E.1,2,3 (AUTHOR); Kmetova, Katarina1,4 (AUTHOR); NaveenKumar, Somanathapura K.4 (AUTHOR); Kluge, Lyndsay4 (AUTHOR); Chong, Emily4 (AUTHOR); Hoy, Claire K.4 (AUTHOR); Yalavarthi, Srilakshmi4 (AUTHOR); Sarosh, Cyrus4 (AUTHOR); Baisch, Jeanine5 (AUTHOR); Walters, Lynnette2 (AUTHOR); Nassi, Lorien1,2,3 (AUTHOR); Fuller, Julie1,2,3 (AUTHOR); Turnier, Jessica L.6 (AUTHOR); Pascual, Virginia5 (AUTHOR); Wright, Tracey B.1,2,3 (AUTHOR); Madison, Jacqueline A.4,6 (AUTHOR); Knight, Jason S.4 (AUTHOR); Zia, Ayesha3,7 (AUTHOR); Zuo, Yu1,4 (AUTHOR)
- Source:
Clinical Immunology. Apr2024, Vol. 261, pN.PAG-N.PAG. 1p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Our study aimed to evaluate the presence, clinical associations, and potential mechanistic roles of non-criteria antiphospholipid antibodies (aPL) and circulating calprotectin, a highly stable marker of neutrophil extracellular trap release (NETosis), in pediatric APS patients. We found that 79% of pediatric APS patients had at least one non-criteria aPL at moderate-to-high titer. Univariate logistic regression demonstrated that positive anti-beta-2 glycoprotein I domain 1 (anti-D1) IgG (p = 0.008), anti-phosphatidylserine/prothrombin (aPS/PT) IgG (p < 0.001), and aPS/PT IgM (p < 0.001) were significantly associated with venous thrombosis. Positive anti-D1 IgG (p < 0.001), aPS/PT IgG (p < 0.001), and aPS/PT IgM (p = 0.001) were also associated with non-thrombotic manifestations of APS, such as thrombocytopenia. Increased levels of calprotectin were detected in children with APS. Calprotectin correlated positively with absolute neutrophil count (r = 0.63, p = 0.008) and negatively with platelet count (r = −0.59, p = 0.015). Mechanistically, plasma from pediatric APS patients with high calprotectin levels impaired platelet viability in a dose-dependent manner. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Clinical Immunology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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