Marking Time: Epigenetic Aging May Partially Explain the Arsenic-Cardiovascular Disease Link.

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      United States
    • Abstract:
      The article discusses research which examined the role of epigenetic aging in the link between arsenic exposure and cardiovascular disease (CVD) among Native American men and women. Study results indicate the association of higher arsenic levels with faster epigenetic aging. It suggests the involvement of DNA methylation in the causal pathways linking arsenic exposure with hallmarks of CVD, such as atherosclerotic lesions, and recommends epigenetic clocks as a tool for evaluating interventions.