Rationale and design of a randomized trial to assess the effects of diuretics in heart failure: Japanese Multicenter Evaluation of Long- vs Short-Acting Diuretics in Congestive Heart Failure (J-MELODIC).

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  • Source:
    Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2007 Jul; Vol. 71 (7), pp. 1137-40.
  • Publication Type:
    Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
  • Language:
    English
  • Additional Information
    • Corporate Authors:
      J-MELODIC Program Committee
    • Source:
      Publisher: Japanese Circulation Society Country of Publication: Japan NLM ID: 101137683 Publication Model: Print Cited Medium: Print ISSN: 1346-9843 (Print) Linking ISSN: 13469843 NLM ISO Abbreviation: Circ J Subsets: MEDLINE
    • Publication Information:
      Original Publication: Kyoto, Japan : Japanese Circulation Society, [2002-
    • Subject Terms:
      Diuretics/*therapeutic use ; Furosemide/*therapeutic use ; Heart Failure/*drug therapy ; Sulfanilamides/*therapeutic use; Adult ; Aged ; Aged, 80 and over ; Delayed-Action Preparations ; Diuretics/pharmacology ; Furosemide/pharmacology ; Heart Failure/diagnosis ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Prognosis ; Prospective Studies ; Single-Blind Method ; Sulfanilamides/pharmacology ; Treatment Outcome
    • Abstract:
      Background: Diuretics are the most prescribed medication for heart failure (HF) patients, but clinical evidence of the long-term effects of diuretics are lacking. The present study was designed to compare the therapeutic effects of furosemide, a short-acting loop diuretic, and azosemide, a long-acting one, in patients with HF to test the hypothesis that long-acting diuretics are superior therapy.
      Methods and Results: The Japanese Multicenter Evaluation of LOng- vs short-acting Diuretics In Congestive heart failure (J-MELODIC) is a multicenter, prospective, randomized trial enrolling a total of 300 patients (150 patients in each group). The primary outcome is a composite of cardiovascular death and unplanned admission to hospital for congestive HF. Other outcomes include all-cause mortality, worsening of the symptoms of HF, or a need for modification of therapy. Serial assessment of echocardiographic and neurohumoral parameters will be conducted over a minimum follow-up period of 2 years.
      Conclusions: The study results will provide important evidence for the treatment of chronic HF.
    • Accession Number:
      0 (Delayed-Action Preparations)
      0 (Diuretics)
      0 (Sulfanilamides)
      7LXU5N7ZO5 (Furosemide)
      MR40VT1L8Z (azosemide)
    • Publication Date:
      Date Created: 20070626 Date Completed: 20070821 Latest Revision: 20190819
    • Publication Date:
      20221213
    • Accession Number:
      10.1253/circj.71.1137
    • Accession Number:
      17587724