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Wando Mount Pleasant Library
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Tipping the balance toward transplantation tolerance: in vivo therapy using a mutated IL-2.
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- Author(s): Camirand, Geoffrey; Lakkis, Fadi G.
- Source:
Journal of Clinical Investigation. 3/1/2024, Vol. 134 Issue 5, p1-3. 3p. - Source:
- Additional Information
- Subject Terms:
- Abstract: Immune tolerance to allogenic transplanted tissues remains elusive, and therapeutics promoting CD4+FOXP3+ Tregs are required to achieve this ultimate goal. In this issue of the JCI, Efe and colleagues engineered an Fc domain fused to a human mutein IL-2 (mIL-2--Fc) bearing mutations that confer preferential binding to the high-affinity IL-2 receptor expressed on Tregs. In vivo mIL-2--Fc therapy effectively heightened mouse, monkey, and human Treg numbers, promoted tolerance to minor antigen mismatched skin grafts in mice, and synergized with immunosuppressive drugs used in the clinic. These findings warrant clinical trials that assess the efficacy of mIL-2--Fc in transplantation. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Clinical Investigation is the property of American Society for Clinical Investigation and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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