Beast of (renal) burden? Bst1-expressing neutrophils in kidney injury.

The article titled "Beast of (renal) burden? Bst1-expressing neutrophils in kidney injury" discusses the role of neutrophils in acute kidney injury (AKI) and the potential therapeutic target of bone marrow stromal cell antigen-1 (Bst1/CD157) in mediating the immune response following AKI. The study found that Bst1-deficient mice exhibited a significant attenuation of AKI compared to wild-type mice, suggesting that Bst1 expression in hematopoietic stem cells, particularly neutrophils, plays a crucial role in inducing AKI. The authors also highlighted the need for further research to understand the cellular and molecular mechanisms of the innate immune system in kidney ischemia. [Extracted from the article]

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