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Bumped pomalidomide-based PROTACs.
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- Author(s): Guo, Huijuan1 (AUTHOR)
- Source:
Communications Chemistry. 2/26/2024, Vol. 7 Issue 1, p1-2. 2p.- Subject Terms:
- Source:
- Additional Information
- Abstract: Pomalidomide is an E3 ligase recruiter exploited by PROTACs to degrade target proteins, but its application is hampered by the off-target degradation of other vital endogenous zinc finger (ZF) proteins. Now, the off-target ZF binding of pomalidomide-based PROTACs is evaluated by a high-throughput imaging screening platform, and minimization of off-target degradation as well as enhanced potency are achieved through selective functionalization at the C5 position of the phthalimide ring. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Communications Chemistry is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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