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Hippo‐YAP signaling activation and cross‐talk with PI3K in oral cancer: A retrospective cohort study.
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- Author(s): Rodrigo, Juan P.; Rodríguez‐Santamarta, Tania; Corte, Daniela; García‐de‐la‐Fuente, Vanessa; Rodríguez‐Torres, Nerea; Lequerica‐Fernández, Paloma; Lorz, Corina; García‐Pedrero, Juana M.; de Vicente, Juan C.
- Source:
Oral Diseases; Mar2024, Vol. 30 Issue 2, p149-162, 14p- Subject Terms:
PROTEINS; STATISTICS; MOUTH tumors; CONFIDENCE intervals; PHOSPHOTRANSFERASES; IMMUNOHISTOCHEMISTRY; MULTIVARIATE analysis; HIPPO signaling pathway; RETROSPECTIVE studies; LYMPH nodes; METASTASIS; CELLULAR signal transduction; RESEARCH funding; HISTOLOGICAL techniques; ALCOHOL drinking; DESCRIPTIVE statistics; SQUAMOUS cell carcinoma; LONGITUDINAL method; CYTOPLASM; TOBACCO - Source:
- Additional Information
- Abstract: Objectives: This study aimed to investigate the clinical and prognostic relevance of the Hippo‐YAP transactivators YAP1 and TAZ in oral squamous cell carcinoma, and their possible relationship with PI3K/mTOR pathway activation. Materials and Methods: Immunohistochemical analysis of YAP1, TAZ, PIK3CA (p110α), p‐AKT (Ser473), and p‐S6 (Ser235) was performed in paraffin‐embedded tissue specimens from 165 OSCC patients. Correlations between protein expression and clinical data were further assessed. Results: YAP1 expression was detected in both cytoplasm and nucleus of tumor cells, whereas TAZ expression was only found in the nucleus. Nuclear YAP1 was significantly associated with tumor size (p = 0.03), neck lymph node metastasis (p = 0.02), TNM stage (p = 0.02), and poor differentiation (p = 0.04). Nuclear TAZ was associated with tobacco (p = 0.03) and alcohol consumption (p = 0.04), and poor tumor differentiation (p = 0.04). There was a positive significant correlation between nuclear and cytoplasmic YAP1, nuclear TAZ, p110α expression, and mTORC1 activation p‐S6 (S235). Combined expression of nuclear and cytoplasmic YAP1 was prognostic in both univariate and multivariate analyses. Active nuclear YAP1 was significantly and independently associated with poor disease‐specific (p = 0.005, HR = 2.520; 95% CI = 1.319–4.816) and overall survival (p = 0.015, HR = 2.126; 95% CI = 1.155–3.916). Conclusion: Nuclear YAP1 is an independent predictor of poor survival in oral squamous cell carcinoma. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Oral Diseases is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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