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[Effect of Ginkgo biloba extract preconditioning on discordant cardiac xenografts].
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- Author(s): Huang XS;Huang XS; Liu X; Chen DZ
- Source:
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine [Zhongguo Zhong Xi Yi Jie He Za Zhi] 2006 Jun; Vol. 26 Suppl, pp. 108-11.
- Publication Type:
Journal Article
- Language:
Chinese
- Additional Information
- Source:
Publisher: Gai yan jiu yuan Country of Publication: China NLM ID: 9211576 Publication Model: Print Cited Medium: Print ISSN: 1003-5370 (Print) Linking ISSN: 10035370 NLM ISO Abbreviation: Zhongguo Zhong Xi Yi Jie He Za Zhi Subsets: MEDLINE
- Publication Information:
Publication: Beijing : Gai yan jiu yuan
Original Publication: Beijing : Gai yan jiu yuan, 1992-
- Subject Terms:
- Abstract:
Objective: To investigate the effect of ginkgo biloba extract (ginaton) preconditioning on discordant cardiac xenografts from guinea pig to rat, and explore its mechanism.
Methods: Cervical cardiac transplantation model was established in the rats,which were divided into 4 groups Group 1 (cobra venom factor ( CVF) pretreatment, n = 10]; Group 2 (CVF + ginaton, n = 5) ; Group 3 Ccyclosporine (CsA); Group 4 (CVF + CsA + ginaton, n = 8]. The survival time and histopathology after xenograft were observed and expressions of intercellular adhesion molecule-1 (ICAM-1) heme oxygenase-1 (HO-1) CD68 and CD57 were detected.
Results: Pathologic manifestion of grafts showed changes of acute vascular rejection (AVR) in all groups. The mean survival time after car diac xenograft was 41 hrs in Group 1, 68 hrs in Group 2, 55 hrs in Group 3 and 74 hrs in Group 4. Expression of intercellular adhesion molecule-1 (ICAM-1 ) decreased after ginaton preconditioning (P < 0. 05). CD68 and CD57 expressions were down-regulated, HO-1 expression was up-regulated, as well as the apoptotic index (Al) reduced significantly after ginaton with cyclosporine A preconditioning.
Conclusion: Ginaton preconditioning can prolong the survival time after discordant xenograft, and significantly alleviate pathological lesion from acute xenograft vascular rejection combined with cyclosporine A.
- Accession Number:
0 (Antigens, CD)
0 (Antigens, Differentiation, Myelomonocytic)
0 (CD57 Antigens)
0 (CD68 protein, rat)
0 (Drugs, Chinese Herbal)
0 (ginaton)
126547-89-5 (Intercellular Adhesion Molecule-1)
EC 1.14.14.18 (Heme Oxygenase-1)
- Publication Date:
Date Created: 20070616 Date Completed: 20100624 Latest Revision: 20171116
- Publication Date:
20231215
- Accession Number:
17569363
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